DIVINYLBENZENE & STODARD SOLVENTS (I-A, II-C)

二乙烯基苯

• 批准号: 6091498
• 负责人: BILLY J CHOU
• 金额: $ 100万
• 依托单位: BATTELLE MEMORIAL INSTITUTE
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-07-31 至 2002-03-20
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6091498
• 关键词: benzene; chemical carcinogen; laboratory mouse; laboratory rat; nonwater solvent; physical chemical interaction; toxicology

The objective of this contract is to determine the potential toxicity/carcinogenicity of three chemicals via the inhalation route of exposure to F344 rats and B6C3F1 mice. The project involves prechronic and chronic studies of divinylbenzene, stoddard solvent (type II-C) and optionally, stoddard solvent (type I-A). The 14-day studies involve the treatment of 5 animals per sex/species at 5 exposure concentrations plus controls. The 90-day studies involve the treatment of 10 animals per sex/species at 5 exposure concentrations plus controls. Special studies in the subchronic study include hematology, clinical chemistries, SMVCE and micronuclei (mice). The 2-year studies involve the treatment of 50 animals per sex/species at 3 exposure concentrations plus controls.

本合同的目的是确定潜力