DIVINYLBENZENE & STODARD SOLVENTS (I-A, II-C)

这份合同的目标是确定潜在的 吸入三种化学物质的毒性/致癌性 F344大鼠和B6C3F1小鼠暴露途径。该项目 涉及二乙烯基苯的慢性前期和慢性研究， 斯托达德溶剂(II-C型)和任选的斯托达德溶剂 (I-A型)。 这项为期14天的研究包括每组5只动物的治疗。 性别/物种在5个暴露浓度加对照。 为期90天的研究包括对每只动物进行10只动物的治疗 性别/物种在5个暴露浓度加对照。特价 亚慢性研究包括血液学、临床 化学、SMVCE和微核(小鼠)。 这项为期两年的研究涉及每只动物50只的治疗。 性别/物种在3个暴露浓度加对照。

The objective of this contract is to determine the potential toxicity/carcinogenicity of three chemicals via the inhalation route of exposure to F344 rats and B6C3F1 mice. The project involves prechronic and chronic studies of divinylbenzene, stoddard solvent (type II-C) and optionally, stoddard solvent (type I-A). The 14-day studies involve the treatment of 5 animals per sex/species at 5 exposure concentrations plus controls. The 90-day studies involve the treatment of 10 animals per sex/species at 5 exposure concentrations plus controls. Special studies in the subchronic study include hematology, clinical chemistries, SMVCE and micronuclei (mice). The 2-year studies involve the treatment of 50 animals per sex/species at 3 exposure concentrations plus controls.