PRECHRONIC DOSED WATER STUDY OF DIPROPYLENE GLYCOL

这个项目的目标是描述剂量反应的特征 丙二醇单剂量给药与毒性的关系 14天重复给药和90天亚慢性给药对大鼠和小鼠的影响 学习。在每项研究结束时，所有动物都将被给予大体和 显微镜下的组织病理学检查。血液学，临床化学， 尿检和精子形态/阴道细胞学检查将在#年进行 这项为期90天的研究。每项研究的结果将被NTP用来 确定将在下一项研究中使用的剂量(即14天结果 对于90天的研究；对于可能的慢性研究的90天结果)。

The objective of this project is to characterize dose-response relationships and toxicity of dipropylene glycol administered by dosed- water to rats and mice in 14-day repeated-dose and 90-day subchronic studies. At the end of each study, all animals will be given gross and microscopic histopathologic evaluations. Hematology, clinical chemistry, urinalysis, and sperm morphology/vaginal cytology will be performed in the 90-day study. The results of each study will be used by NTP to establish doses to be used in the next study (i.e., the 14-day results for the 90-day study; the 90-day results for a possible chronic study).