PRECHRONIC DOSED WATER STUDY OF DIPROPYLENE GLYCOL

本项目的目标是描述剂量反应 的关系和毒性的二丙二醇管理的剂量- 大鼠和小鼠14天重复给药和90天亚慢性给药 问题研究在每次研究结束时，将对所有动物进行大体和 显微镜组织病理学评价。血液学，临床化学， 将进行尿液分析和精子形态学/阴道细胞学检查， 90天的研究NTP将使用每项研究的结果， 确定下一项研究中使用的剂量（即，14天的结果 对于90天研究;对于可能的长期研究的90天结果）。

The objective of this project is to characterize dose-response relationships and toxicity of dipropylene glycol administered by dosed- water to rats and mice in 14-day repeated-dose and 90-day subchronic studies. At the end of each study, all animals will be given gross and microscopic histopathologic evaluations. Hematology, clinical chemistry, urinalysis, and sperm morphology/vaginal cytology will be performed in the 90-day study. The results of each study will be used by NTP to establish doses to be used in the next study (i.e., the 14-day results for the 90-day study; the 90-day results for a possible chronic study).