PRECHRONIC DOSED WATER STUDY OF DIPROPYLENE GLYCOL

二丙二醇的慢性定量水研究

• 批准号: 3642360
• 负责人: ANTHONY GRAFFEO
• 金额: $ 14.93万
• 依托单位: ARTHUR D. LITTLE, INC.
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-09-15 至 1991-05-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3642360
• 关键词: blood chemistry; cytology; dosage; histopathology; laboratory mouse; laboratory rat; microscopy; morphology; propylene glycols; sperm; toxicant screening; urinalysis; vagina

The objective of this project is to characterize dose-response relationships and toxicity of dipropylene glycol administered by dosed- water to rats and mice in 14-day repeated-dose and 90-day subchronic studies. At the end of each study, all animals will be given gross and microscopic histopathologic evaluations. Hematology, clinical chemistry, urinalysis, and sperm morphology/vaginal cytology will be performed in the 90-day study. The results of each study will be used by NTP to establish doses to be used in the next study (i.e., the 14-day results for the 90-day study; the 90-day results for a possible chronic study).

这个项目的目的是表征剂量反应