CLINICAL TRIALS CENTER FOR ALLHAT

这项计划的目的是进行实践性、随机性的 抗高血压药物治疗的临床试验和在一项 40,000名高危高血压患者中的特定亚型降脂 包括至少55%的非洲裔美国人。该计划的目的是 抗高血压试验是为了确定是否合并高血压的发病率 致命性冠心病(CHD)和非致命性心肌梗死 利尿剂治疗和三种替代降压药之间的差异 药物治疗：一种钙拮抗剂，一种血管紧张素转换 酶(ACL)抑制剂和α-肾上腺素能阻滞剂。 降胆固醇成分的目的是确定 降低中度高胆固醇血症男性的血清胆固醇和 患有3-羟甲基丙二酰辅酶A的60岁及以上女性 (HMG CoA)还原酶抑制剂将降低死亡的联合发生率 冠心病和非致命性心肌梗死。包括胆固醇- 降低组分取决于获得HMG-CoA还原酶 抑制剂，目前尚未最后敲定。批准继续进行 降脂试验将在可用之前不会被批准 这名特工的身份已经得到保护。 而不是使用独立资助的诊所，将招募患者 通过办公室实践和高血压诊所，这将是 由临床试验中心(CTC)按每位患者报销。 这份合同是关于临床试验中心的。的一些功能 临床试验中心包括协调所有数据收集， 数据存储、与研究有关的分析活动以及招聘 和培训(与NHLBI一起)适当的临床站点和核心 需要进行这项研究的实验室。

The purpose of this program is to conduct a practice-based, randomized clinical trial of antihypertensive pharmacologic treatment and, in a specific subset, lipid-lowering, in 40,000 high-risk hypertensive patients including at least 55% African-Americans. The purpose of the antihypertensive trial is to determine whether the combined incidence of fatal coronary heart disease (CHD)) and non-fatal myocardial infarction differs between diuretic treatment and three alternative antihypertensive pharmacologic treatments: a calcium antagonist, an angiotensin converting enzyme (ACL) inhibitor, and an alpha adrenergic blocker. The purpose of the cholesterol-lowering component is to determine whether lowering serum cholesterol in moderately hypercholesterolemic men and women aged 60 years and older with a 3-hydroxymethylgiutaryl coenzyme A (HMG CoA) reductase inhibitor will reduce the combined incidence of fatal CHD and non-fatal myocardial infarction. Inclusion of the cholesterol- lowering component is contingent on obtaining an HMG-CoA reductase inhibitor, which has not been finalized at this time. Approval to proceed with the lipid-lowering trial will not be granted until the availability of this agent has been secured. Rather than using independently funded clinics, patients will be recruited through office-based practices and hypertension clinics which will be reimbursed by the Clinical Trials Center (CTC) on a per-patient basis. This contract is for the Clinical Trials Center. Some of the functions of the Clinical Trials Center include coordinating all data collection, storage of data, analysis activities related to the study, and recruiting and training (along with the NHLBI) appropriate clinical sites and core laboratories required to conduct the study.