CHRONIC STUDIES OF COCONUT OIL FATTY ACIDS

这份合同的目的是进行为期90天和2年的学习 进行油脂脂肪酸、月桂酸和油酸二乙醇胺 F344大鼠和B6C3F1小鼠皮肤涂膜给药途径。 具体来说，对三种二乙醇胺进行为期90天的研究将是 指挥。每组10只动物/性别/物种(5个处理组和1个 对照)将接受90天的治疗。完全尸检和组织病理学 将在所有动物身上进行。此外，临床化学和 血液学将在大鼠身上进行评估，SMVCE在大鼠和小鼠身上进行评估。特价 毒代动力学研究将在小鼠和大鼠身上进行。此外， 承包商应对每种二乙醇胺进行为期104周的研究。五十 每个治疗组的动物/性别/物种应在3点治疗104周 剂量水平加对照。急性淋巴细胞白血病的完整组织病理学评估 应表演动物。

The purpose of this contract is to conduct 90-day and 2-year studies with conduct oil fatty acids, lauric acid, and oleic acid Diethanolamines by the skin paint route of administration in F344 rats and B6C3F1 mice. Specifically, a 90-day study with each of the three diethanolamines will be conducted. Ten animals/sex/species per treatment group (5 treatment and a control) will be treated for 90 days. Complete necropsy and histopathology are to performed on all animals. In addition, clinical chemistry and hematology will be evaluated in rats and SMVCE in rats and mice. Special toxicokinetic studies will be conducted in mice and rats. In addition, the contractor shall conduct 104-week studies with each Diethanolamine. Fifty animals/sex/specie per treatment group shall be treated for 104 weeks at 3 dose levels plus controls. Complete histopathologic evaluation of all animals shall be performed.