CHRONIC STUDIES OF COCONUT OIL FATTY ACIDS

该合同的目的是进行为期90天和2年的研究， 脂肪酸、月桂酸和油酸二乙醇胺的传导 F344大鼠和B6 C3 F1小鼠皮肤涂抹给药途径。 具体而言，将对三种二乙醇胺中的每一种进行为期90天的研究， 进行。 每个处理组10只动物/性别/种属（5个处理组和1个处理组） 对照组）治疗90天。 完成尸检和组织病理学检查 在所有动物身上进行。 此外，临床化学和 将在大鼠中评价血液学，在大鼠和小鼠中评价SMVCE。 特别 将在小鼠和大鼠中进行毒代动力学研究。 此外该 承包商应对每种二乙醇胺进行104周的研究。 五十 每个处理组的动物/性别/种属应在3 剂量水平加对照。 对所有患者进行完整的组织病理学评价 动物将被执行。

The purpose of this contract is to conduct 90-day and 2-year studies with conduct oil fatty acids, lauric acid, and oleic acid Diethanolamines by the skin paint route of administration in F344 rats and B6C3F1 mice. Specifically, a 90-day study with each of the three diethanolamines will be conducted. Ten animals/sex/species per treatment group (5 treatment and a control) will be treated for 90 days. Complete necropsy and histopathology are to performed on all animals. In addition, clinical chemistry and hematology will be evaluated in rats and SMVCE in rats and mice. Special toxicokinetic studies will be conducted in mice and rats. In addition, the contractor shall conduct 104-week studies with each Diethanolamine. Fifty animals/sex/specie per treatment group shall be treated for 104 weeks at 3 dose levels plus controls. Complete histopathologic evaluation of all animals shall be performed.