Novel green scalable chemical peptide synthesis and enzyme immobilization

新型绿色可规模化学肽合成和酶固定化

• 批准号: LP180101006
• 负责人: Prof John Wade
• 金额: $ 33.12万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Projects
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-12-17 至 2023-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LP180101006
• 关键词: Novel; green; scalable; chemical; peptide

The Project aims to address the critical issue of developing green processes for the chemical production of peptides including on an industrial scale. It will use unique, biocompatible solid supports that have been invented by our partner SpheriTech Ltd together with other reagents to allow synthesis to be conducted in water rather than toxic organic solvents. Expected outcomes of the Project include an international partnership in highly efficient environmentally-friendly assembly of peptides and of their analogues by both solid phase synthesis and immobilized enzyme-mediated ligation. The clear benefit will be the first novel, water-based, scalable green synthesis of peptides as biological probes and potential therapeutic agents.

该项目旨在解决开发用于化学生产肽的绿色工艺的关键问题，包括工业规模。它将使用由我们的合作伙伴SpheriTech Ltd发明的独特的生物相容性固体支持物以及其他试剂，以允许在水中而不是有毒有机溶剂中进行合成。该项目的预期成果包括通过固相合成和固定化酶介导的连接在高效环境友好的肽及其类似物组装方面建立国际伙伴关系。明显的好处将是第一个新的，水基的，可扩展的绿色合成肽作为生物探针和潜在的治疗剂。