CHEMICAL DISPOSITION

化学处置

• 批准号: 2308504
• 负责人: A R JEFFCOAT
• 金额: $ 91.54万
• 依托单位: RESEARCH TRIANGLE INSTITUTE
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-09-30 至 1996-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2308504
• 关键词: CHEMICAL; DISPOSITION

The purpose of this project, entitled "Studies of Chemical Disposition in Mammals", is to procure chemical disposition studies to be performed in support of the toxicity and carcinogenicity studies conducted by the National toxicology Program (NTP). This program is designed to provide data on acute and chronic toxicity which may result from exposure to selected chemicals. The Contractor shall conduct 6-10 chemical disposition and toxicokinetic studies per year. The results of these studies provide the basis for predictions of bioaccumulation and toxicity and thereby enhance the accuracy of dose selection as well as improve the design of the animal bioassay program. Furthermore, chemical disposition and toxicokinetic studies provide information which will allow the NTP to establish the relationships between toxicity and bioavailability of chemicals and/or metabolites and permits a better extrapolation of laboratory data to humans. The contracts obtained under this project will continue the work under predecessor contracts N01ES65137 and N01ES65138.

该项目的目的，题为“化学处置的研究