RETINAL ARTERY READING CENTER FOR THE ARIC STUDY

本合同的目的是提供阅读服务 中心解读来自大约14,500张视网膜的照片 检查(包括一小部分盲复制 照片)，在该地区的流行病学研究中进行 影响心血管疾病发生和发展趋势的主要因素 题为《动脉粥样硬化风险》的中年疾病 社区研究(ARIC)。视网膜动脉阅读中心将协助 视网膜动脉功能检查方案的制定 在四个ARIC外地中心进行考试，并将执行 这些图像的测量和解释以标准化和 可复制的方式。 视网膜动脉阅读中心的主要目标是开发， 实施并监控视网膜协议的性能 社区中动脉粥样硬化风险的摄影检查 学习。这一额外组成部分的目标是： 1.评估和量化视网膜与视网膜之间的独立关系 动脉硬化和心血管事件的发生。 2.检查心血管疾病风险因素和事件概况之间的差异 视网膜动脉硬化和颈动脉粥样硬化。 3.确定视网膜动脉硬化与糖尿病的关系 脑部MRI表现，包括梗死样病变和小白斑 物质损伤。 4.对比以下脑部MRI表现的特点 视网膜动脉硬化和颈动脉粥样硬化。 5.评估视网膜动脉硬化与糖尿病的关系 认知能力下降。

The purpose of this contract is to provide the services of a reading center to interpret photographs from approximately 14,500 retinal examinations (including a small percentage of blind replicate photographs), performed in the epidemiological research study of the major factors contributing to the occurrence and trends of cardiovascular disease in middle-aged adults entitled "Atherosclerosis Risk in Communities Study (ARIC)". The Retinal Artery Reading Center will assist in protocol development for the performance of retinal artery examinations in the four ARIC Field Centers, and will perform measurements and interpretations of these images in a standardized and reproducible manner. The primary objective of the Retinal Artery Reading Center is to develop, implement, and monitor performance of a protocol for the retinal photography examinations within the Atherosclerosis Risk in Communities Study. The objectives of this additional component are: 1. To assess and quantitate the independent relationship between retinal arteriosclerosis and incident CVD events. 2. To examine differences between the CVD risk factor and event profiles of retinal arteriosclerosis and carotid atherosclerosis. 3. To determine the association between retinal arteriosclerosis and cerebral MRI findings, including infarct-like lesions and small white matter lesions. 4. To contrast the profiles of cerebral MRI findings associated with retinal arteriosclerosis and carotid atherosclerosis. 5. To assess the relationship between retinal arteriosclerosis and cognitive decline.