Diabetic Retinopathy Clinical Research Network

糖尿病视网膜病变临床研究网络

• 批准号: 6740116
• 负责人: MATTHEW D DAVIS
• 金额: $ 36.61万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-30 至 2008-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6740116
• 关键词: angiography; bioimaging /biomedical imaging; biomedical resource; cooperative study; diabetic retinopathy; digital imaging; edema; eye disorder diagnosis; eye fundus photography; image processing; medical complication; retina disorder; retinography

DESCRIPTION (provided by applicant): The University of Wisconsin Fundus Photograph Reading Center (UW FPRC) proposes to serve as photograph reading center for the DME Clinical Research Network. To accomplish this, we propose to: (I) Collaborate with other network investigators to develop ideas for clinical trials of promising new DME treatments, construct study protocols, carry out approved studies, analyze the resultant data, and prepare manuscripts. (2) Adapt or develop procedures for documenting and grading DME. We can provide protocols for DME imaging (color stereoscopic fundus photographs, fluorescein angiograms, and optical coherence tomograms), and are experienced at orienting, certifying, and giving feedback to clinic photographers. By extending the Early Treatment Diabetic Retinopathy Study classification, we have protocols for evaluation/grading of DME from color photographs and angiograms. We are developing a protocol for assessment of OCT scans. We are prepared to modify these protocols further, if necessary, to define the eligibility and outcome criteria appropriate to network goals. The UW FPRC principal investigator and staff are experienced at participation in collaborative multi-center clinical trials (e.g., Diabetic Retinopathy Study, Early Treatment of Diabetic Retinopathy Study, Diabetes Control and Complications Trial, and several drug trials) and in networks to conduct them (e.g., the Study of the Ocular Complications of AIDS), and are strongly committed to the study of DME and its potential treatments as a major public health priority.

描述（由申请人提供）：威斯康星州大学眼底照片阅读中心（UW FPRC）拟作为DME临床研究网络的照片阅读中心。为此，我们建议： (I)与其他网络研究人员合作，为有前途的新DME治疗方法的临床试验开发想法，构建研究方案，进行批准的研究，分析结果数据，并准备手稿。 (2)调整或制定记录和分级DME的程序。我们可以提供DME成像协议（彩色立体眼底照片，荧光素血管造影和光学相干断层扫描），并在定向，认证和向临床摄影师提供反馈方面经验丰富。通过扩展早期治疗糖尿病视网膜病变研究分类，我们有了根据彩色照片和血管造影片对DME进行评估/分级的方案。我们正在制定一项评估OCT扫描的方案。如有必要，我们准备进一步修改这些协议，以确定适合网络目标的资格和结果标准。 UW FPRC的主要研究者和工作人员在参与协作多中心临床试验方面经验丰富（例如，糖尿病视网膜病变研究、糖尿病视网膜病变的早期治疗研究、糖尿病控制和并发症试验以及若干药物试验）以及开展这些试验的网络（例如，艾滋病眼部并发症的研究），并坚定地致力于DME及其潜在治疗的研究，作为一个主要的公共卫生优先事项。