Diabetic Retinopathy Clinical Research Network

糖尿病视网膜病变临床研究网络

• 批准号: 6665275
• 负责人: MATTHEW D DAVIS
• 金额: $ 38.98万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-30 至 2009-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6665275
• 关键词: angiography; bioimaging /biomedical imaging; biomedical resource; clinical research; clinical trials; cooperative study; diabetic retinopathy; digital imaging; edema; eye disorder diagnosis; eye fundus photography; image processing; medical complication; retina disorder; retinography

DESCRIPTION (provided by applicant): The University of Wisconsin Fundus Photograph Reading Center (UW FPRC) proposes to serve as photograph reading center for the DME Clinical Research Network. To accomplish this, we propose to: (I) Collaborate with other network investigators to develop ideas for clinical trials of promising new DME treatments, construct study protocols, carry out approved studies, analyze the resultant data, and prepare manuscripts. (2) Adapt or develop procedures for documenting and grading DME. We can provide protocols for DME imaging (color stereoscopic fundus photographs, fluorescein angiograms, and optical coherence tomograms), and are experienced at orienting, certifying, and giving feedback to clinic photographers. By extending the Early Treatment Diabetic Retinopathy Study classification, we have protocols for evaluation/grading of DME from color photographs and angiograms. We are developing a protocol for assessment of OCT scans. We are prepared to modify these protocols further, if necessary, to define the eligibility and outcome criteria appropriate to network goals. The UW FPRC principal investigator and staff are experienced at participation in collaborative multi-center clinical trials (e.g., Diabetic Retinopathy Study, Early Treatment of Diabetic Retinopathy Study, Diabetes Control and Complications Trial, and several drug trials) and in networks to conduct them (e.g., the Study of the Ocular Complications of AIDS), and are strongly committed to the study of DME and its potential treatments as a major public health priority.

描述(由申请人提供)：威斯康星大学眼底照片阅读中心(UW FPRC)建议作为DME临床研究网络的照片阅读中心。为达致这个目标，我们建议： (I)与其他网络调查人员合作，为有希望的二甲基醚新疗法的临床试验制定想法，构建研究方案，开展经批准的研究，分析结果数据，并准备手稿。 (2)修改或制定记录和分级DME的程序。我们可以提供DME成像方案(彩色立体眼底照片、荧光素血管成像和光学相干断层扫描)，并在定位、认证和向临床摄影师提供反馈方面经验丰富。通过扩展早期治疗糖尿病视网膜病变研究分类，我们制定了从彩色照片和血管造影对DME进行评估/分级的方案。我们正在制定一项评估OCT扫描的方案。如有必要，我们准备进一步修改这些协议，以确定适用于网络目标的资格和结果标准。 威斯康星大学视网膜病变研究中心的首席研究员和工作人员在参与多中心合作临床试验(例如糖尿病视网膜病变研究、糖尿病视网膜病变早期治疗研究、糖尿病控制和并发症试验，以及几项药物试验)和实施这些试验的网络(例如艾滋病的眼部并发症研究)方面经验丰富，并坚定地致力于将二甲基醚及其潜在治疗方法作为主要公共卫生优先事项的研究。