STUDY OF PEDIATRIC LUNG & HEART COMPLICATIONS OF HIV

儿科肺部研究

• 批准号: 2317425
• 负责人: Mark D. Schluchter
• 金额: $ 53.25万
• 依托单位: CLEVELAND CLINIC FOUNDATION
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-05-01 至 1995-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2317425
• 关键词: STUDY; PEDIATRIC; LUNG; HEART; COMPLICATIONS

The overall objective of this program is to conduct a "natural" history study to characterize the pulmonary and cardiovascular disorders that occur in association with vertically transmitted (mother to child during gestation or during the perinatal time period) human immunodeficiency virus (HIV) infection in children. The study will be coordinated among six geographically separated centers (Baylor College of Medicine, Houston; Children's Hospital/Harvard Medical School, Boston; Mt. Sinai School of Medicine, New York City; Presbyterian Hospital/Columbia University, New York City; UCLA School of Medicine, Los Angeles; and University of California, San Francisco) and the Clinical Coordinating Center (The Cleveland Clinic Foundation). The Program of the Clinical Coordinating Center will include participation in the development of the study protocol, the detailed manual of operations, appropriate data acquisition via distributed data entry, and establishment of suitable data processing procedures. A major activity of the Clinical Coordinating Center will be the development of procedures for control of the quality of the data. A comprehensive program of data management for the Natural History Study will include data review and editing, reduction, display and analysis, and generation of reports and publications.

这个项目的总体目标是引导一段“自然”的历史 对肺部和心血管疾病的特征研究 与垂直传播(母婴传播)相关 孕期或围产期)人类免疫缺陷 儿童感染病毒(HIV)。这项研究将在以下方面进行协调 六个地理上分离的中心(贝勒医学院， 波士顿儿童医院/哈佛医学院；西奈半岛 纽约市医学院；哥伦比亚长老会医院 纽约大学；洛杉矶加州大学洛杉矶分校医学院；以及 加州大学旧金山分校)和临床协调 中心(克利夫兰诊所基金会)。 临床协调中心的计划将包括 参与研究方案的制定，详细说明 操作手册，通过分布式数据进行适当的数据采集 进入，并建立适当的数据处理程序。一个 临床协调中心的主要活动将是 制定数据质量控制程序。一个 自然史研究数据管理综合方案 将包括数据审查和编辑、缩减、显示和分析， 以及报告和出版物的生成。