Non-invasive safe electrical stimulation using AI to save lives

利用人工智能进行无创安全电刺激来拯救生命

• 批准号: 61770
• 金额: $ 8.27万
• 依托单位: BRAINPATCH LTD
• 依托单位国家: 英国
• 项目类别: Feasibility Studies
• 财政年份: 2020
• 资助国家: 英国
• 起止时间: 2020 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=61770
• 关键词: Non; invasive; safe; electrical; stimulation

Stress and mental health issues have taken the world over by storm during the ongoing COVID-19 pandemic. There is a growing awareness that managing mental wellbeing in our society is critical. While a variety of pharmaceutical and natural/alternative solutions provide some support for our mental health, the medicines give you very little control and can have severe side effects. The natural remedies are modestly effective at best. Wouldn’t it be great if we could control your mental wellbeing at the touch of a button and even potentially save lives by careful personalised monitoring and management of mental health and wellbeing in key personnel? At BrainPatch we are a team of scientists and experienced entrepreneurs backed by world-class expert advisors. Our aim is to develop a platform technology of safe and effective brain stimulation for a range of applications. We have originally proposed to use non-invasive vagus nerve stimulation to regulate the immune system in critically ill Covid-19 patients. While this was shown to be effective with invasive vagus nerve stimulation in patients with autoimmune disorders and rheumatoid arthritis, it was not tested in Covid-19 patients and we came across a reluctance from doctors to test our approach with their critically ill Covid-19 patients especially as dexamethasone has evolved as a reliable and tested standard of care for the purpose of regulating immune response. So, taking this into consideration and also considering the emerging mental health crisis related to the pandemic we are proposing a change of the project scope. We propose to re-use the equipment, algorithms and parts of the protocol we generated at the start of the project for the purpose of dealing with a rise in stress and mental fatigue seen in the majority of the population. This project aims to bring the company closer to putting this solution in the hands of people, who would want to have a personalised app to cope with stress. This project also lays the ground for further research aimed at putting this technology in the hands of the doctors taking care of patients with mental health issues or those suffering from syndrome of chronic fatigue and inflammation in “long-Covid”.

在2019冠状病毒病大流行期间，压力和心理健康问题席卷了全世界。人们越来越意识到，在我们的社会中，管理心理健康是至关重要的。虽然各种各样的药物和天然/替代解决方案为我们的心理健康提供了一些支持，但这些药物给你的控制很少，而且可能有严重的副作用。这些自然疗法充其量也只是适度有效。如果我们能按下一个按钮就能控制你的心理健康，甚至有可能通过对关键人员的心理健康和健康进行仔细的个性化监测和管理来挽救生命，这不是很好吗？在BrainPatch，我们是一个由科学家和经验丰富的企业家组成的团队，由世界级的专家顾问支持。我们的目标是开发一种安全有效的脑刺激平台技术，用于一系列应用。我们最初提出使用非侵入性迷走神经刺激来调节Covid-19危重患者的免疫系统。虽然这被证明对自身免疫性疾病和类风湿性关节炎患者的侵袭性迷走神经刺激有效，但没有在Covid-19患者中进行测试，我们发现医生不愿意在他们的重症Covid-19患者中测试我们的方法，尤其是在地塞米松已经发展成为一种可靠且经过测试的调节免疫反应的护理标准的情况下。因此，考虑到这一点，也考虑到与大流行有关的新出现的心理健康危机，我们提议改变项目范围。我们建议重新使用我们在项目开始时生成的设备、算法和部分协议，以应对大多数人面临的压力和精神疲劳的增加。该项目旨在使公司更接近将这种解决方案交到人们手中，人们希望有一个个性化的应用程序来应对压力。该项目还为进一步的研究奠定了基础，目的是将这项技术交到照顾精神健康问题患者或患有慢性疲劳和炎症综合征的“长期covid”的医生手中。