FASEB CONFERENCE ON UBIQUITIN AND PROTEIN DEGRADATION

FASEB 泛素和蛋白质降解会议

• 批准号: 2024156
• 负责人: ARTHUR L HAAS
• 金额: $ 0.2万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-06-28 至 1998-06-27
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2024156
• 关键词: meeting /conference /symposium; protein degradation; ubiquitin

DESCRIPTION: This application requests partial funding for a conference on Ubiquitin and Intracellular Protein Degradation to be held 28 June 1997 through 3 July 1997 at the conference Center of Vermont Academy, Saxtons River, VT. This Biennial conference, which was initiated in 1989, is sponsored by and receives partial funding from the Federation of the American Societies of Experimental Biology (FASEB). It is the only regularly scheduled international meeting devoted to this important area of research. The mechanisms and regulation of intracellular protein degradation are of fundamental importance in determining the overall protein content and steady state levels of particular intracellular proteins. The central pathway of protein turnover within eucaryotes is ubiquitin- and ATP-dependent and requires the 26S proteasome. Ubiquitin is a low molecular weight, highly conserved polypeptide that exerts it biological effect through its covalent conjugation to other proteins in an enzymatic pathway requiring ATP hydrolysis. The ligation of ubiquitin to proteins, or more correctly the formation of multiubiquitin chains, serves as a recognition signal for binding of the target protein to the 26S proteasome through specific interaction with subunit 5a of the 19S regulatory complex of the proteasome. This pathway is responsible for the degradation of constitutively and conditionally short-lived proteins including those of abnormal structure generated by environmental stress or mutation as well as various other key regulatory proteins including transcription factors, oncogenes, membrane receptors, and cyclins. The 1997 meeting will be organized into nine sessions comprised of five talks each. Two sessions, comprised of seven talks each, will be composed of speakers chosen from submitted abstracts of participants based on scientific content with special attention given to younger investigators. Ample time will be reserved between all presentations for questions and discussion by the audience. In addition, two poster sessions are planned to allow all participants to present recent findings.

描述：此应用程序请求为一个会议提供部分资金 泛素和细胞内蛋白质降解将于1997年6月28日举行 至1997年7月3日，在萨克斯顿佛蒙特州学院会议中心举行 佛蒙特州里弗市这次两年一度的会议于1989年发起，是 由The Federation of the Federation赞助并获得部分资助 美国实验生物学学会。这是唯一的 定期安排的国际会议，专门讨论这一重要领域 研究。 细胞内蛋白质降解的机制和调节是 在确定总体蛋白质含量和稳定性方面的基础重要性 说明特定细胞内蛋白质的水平。中枢神经通路 真核生物内的蛋白质周转是泛素和三磷酸腺苷依赖的 需要26S蛋白酶体。泛素是一种低分子量，高度 通过共价发挥生物学效应的保守多肽 需要三磷酸腺苷的酶途径中与其他蛋白质的结合 水解液。泛素与蛋白质的连接，或者更准确地说， 形成多泛素链，作为识别信号 目的蛋白通过特异性结合到26S蛋白酶体 与蛋白酶体19S调控复合体的亚基5a相互作用。 这一途径导致了结构性和结构性的降解。 条件性短寿命蛋白质，包括结构异常的蛋白质 由环境压力或突变以及各种其他关键因素产生 调控蛋白包括转录因子、癌基因、膜 受体和细胞周期蛋白。 1997年会议将安排为九届会议，每届会议五次 每个人都在谈话。将组成两个会议，每个会议包括七个演讲 从提交的参与者摘要中选择的演讲者人数 科学内容，特别关注年轻的调查人员。 将在所有问题和问题陈述之间预留充足的时间 观众的讨论。此外，还计划举行两次海报会议，以 允许所有参与者展示最新发现。