FASEB CONFERENCE ON UBIQUITIN AND PROTEIN DEGRADATION

描述：此申请要求为以下会议提供部分资金： 泛素和细胞内蛋白质降解将于 1997 年 6 月 28 日举行 至 1997 年 7 月 3 日，在 Saxtons 佛蒙特学院会议中心 佛蒙特州河 本次会议每两年举办一次，于 1989 年召开。 由联合会赞助并接受部分资助 美国实验生物学会 (FASEB)。 这是唯一的 定期举行专门讨论这一重要领域的国际会议 研究。 细胞内蛋白质降解的机制和调控是 对于确定总蛋白质含量和稳定蛋白质含量至关重要 特定细胞内蛋白质的状态水平。 的中央通路 真核生物内的蛋白质周转依赖于泛素和 ATP 需要26S蛋白酶体。 泛素是一种低分子量、高 保守的多肽，通过其共价键发挥其生物效应 在需要 ATP 的酶促途径中与其他蛋白质缀合 水解。 泛素与蛋白质的连接，或更准确地说是 形成多泛素链，作为识别信号 目标蛋白通过特异性结合到 26S 蛋白酶体上 与蛋白酶体 19S 调节复合物的亚基 5a 相互作用。 该途径负责组成型和 有条件地短寿命的蛋白质，包括结构异常的蛋白质 由环境压力或突变以及其他各种关键因素产生 调节蛋白，包括转录因子、癌基因、膜 受体和细胞周期蛋白。 1997年的会议将分为九次会议，其中包括五次会议 各讲各话。 将分为两场会议，每场由七个演讲组成 从参与者提交的摘要中选出的演讲者基于 特别关注年轻研究人员的科学内容。 所有演示之间将预留充足的时间供提问和讨论 观众的讨论。 此外，还计划举办两次海报展示会 让所有参与者展示最新的发现。

DESCRIPTION: This application requests partial funding for a conference on Ubiquitin and Intracellular Protein Degradation to be held 28 June 1997 through 3 July 1997 at the conference Center of Vermont Academy, Saxtons River, VT. This Biennial conference, which was initiated in 1989, is sponsored by and receives partial funding from the Federation of the American Societies of Experimental Biology (FASEB). It is the only regularly scheduled international meeting devoted to this important area of research. The mechanisms and regulation of intracellular protein degradation are of fundamental importance in determining the overall protein content and steady state levels of particular intracellular proteins. The central pathway of protein turnover within eucaryotes is ubiquitin- and ATP-dependent and requires the 26S proteasome. Ubiquitin is a low molecular weight, highly conserved polypeptide that exerts it biological effect through its covalent conjugation to other proteins in an enzymatic pathway requiring ATP hydrolysis. The ligation of ubiquitin to proteins, or more correctly the formation of multiubiquitin chains, serves as a recognition signal for binding of the target protein to the 26S proteasome through specific interaction with subunit 5a of the 19S regulatory complex of the proteasome. This pathway is responsible for the degradation of constitutively and conditionally short-lived proteins including those of abnormal structure generated by environmental stress or mutation as well as various other key regulatory proteins including transcription factors, oncogenes, membrane receptors, and cyclins. The 1997 meeting will be organized into nine sessions comprised of five talks each. Two sessions, comprised of seven talks each, will be composed of speakers chosen from submitted abstracts of participants based on scientific content with special attention given to younger investigators. Ample time will be reserved between all presentations for questions and discussion by the audience. In addition, two poster sessions are planned to allow all participants to present recent findings.