GORDON CONFERENCE ON GENETIC TOXICOLOGY, 1997

描述：(改编自《调查员摘要》)申请资金 以支持参加会议的科学家的旅费和/或注册费 1997年戈登遗传毒理学研究会议。这是一年半期 会议将于6月在新伦敦的科尔比-索耶学院举行 22-27。从历史上看，参加会议的人都是 来自工业界、学术界、政府研究实验室和联邦政府 来自世界各地的监管机构。会议主席、演讲者、 讨论负责人都是遗传毒物学领域的专家， 突变、致癌、DNA修复或流行病学。遗传 毒理学是一个致力于鉴定基因来源的领域。 关于损害的定义以及发生损害的机制的定义。 因此，遗传毒理学领域必然依赖于数据和 来自一系列科学学科的见解。会话是 旨在让这些领域的专家讨论当前的结果；以及， 为广泛的讨论提供了时间，这两个问题都紧随其后 研究报告和讨论环节。最后， 几张精选海报的调查人员，每一张海报都有相关结果 会议将被要求做简短的陈述(5分钟，2-3张幻灯片) 在讨论过程中。这些演示文稿旨在提供 更广泛参与会议的机会，特别是 学生和博士后研究员。 1997年会议将扩大我们对以下进程的理解： 基因组的稳定性，尤其是在接触诱变剂或致癌物之后。 简而言之，这些会议将讨论：1)正常和异常的DNA代谢 和复制；2)正常和治疗介导的细胞对DNA的反应 3)转基因系统在体内评价中的应用 突变；4)皮肤肿瘤转化的分子方面；5) 最先进的技术检测DNA损伤，基因突变， 或基因组不稳定，以及6)遗传效应的分子证据 暴露在人群中。将在这些地区举办专题讲座 DNA聚合酶的保真度(T.kunkel)，DNA的生物学后果 损伤(B.Glickman)和影响基因组不稳定性的因素(M. 拉德曼)。这类研究与人类癌症的病因学直接相关。 并评估新诱导的生殖系突变的风险。最后， 戈登遗传学会议预期的结果和讨论 毒理学将为更准确地估计健康状况提供基础 基因毒剂的风险，并应提供对联邦政府至关重要的数据 有关药品或化学品安全的监管决定。

DESCRIPTION: (Adapted from the Investigator's Abstract) Funds are requested in support of travel and/or registration costs for scientists attending the 1997 Gordon Research Conference on Genetic Toxicology. This bi-annual conference will be held at Colby-Sawyer College in New London, NH from June 22-27. Attendance at the conference has historically drawn participants from industry, academia, government research laboratories, and federal regulatory agencies from throughout the world. Session chairs, speakers, and discussion leaders are all experts in the fields of genetic toxicology, mutagenesis, carcinogenesis, DNA repair, or epidemiology. Genetic toxicology is a field dedicated to the identification of sources of genetic damage and to the definition of the mechanisms whereby such damage occurs. As such, the field of genetic toxicology necessarily relies upon data and insights drawn from a range of scientific disciplines. Sessions are designed to allow experts in these fields to discuss current results; and, time is provided for extensive discussions, both immediately following research presentations and in the discussion sessions. Finally, investigators of a few selected posters with results relevant to each session will be asked to make brief presentations (5 minute, 2-3 slides) during the discussion sessions. These presentations are intended to provide an opportunity for more broad conference participation, especially for students and postdoctoral fellows. The 1997 conference will extend our understanding of processes that impact genome stability especially following exposure to mutagens or carcinogens. Briefly, the sessions will address: 1) normal and aberrant DNA metabolism and replication; 2) normal and treatment mediated cellular responses to DNA damage; 3) applications of transgenic systems to the assessment of in vivo mutations; 4) molecular aspects of neoplastic transformation in the skin; 5) state-of-the-art techniques for the detection of DNA damage, gene mutations, or genomic instability, and 6) molecular evidence of the genetic effects in exposed human populations. Special lectures will be presented in the areas of DNA polymerase fidelity (T. Kunkel), biological consequences of DNA damage (B. Glickman), and factors influencing genomic instability (M. Radman). Such studies have direct relevance to the etiology of human cancer and to assessing the risk of newly induced germline mutations. Finally, the results and discussions anticipated at the Gordon Conference on Genetic Toxicology will provide a basis for more accurate estimates of the health risks of genotoxic agents and should provide data critical to the federal regulatory decisions concerning drug or chemical safety.