GORDON CONFERENCE ON GENETIC TOXICOLOGY, 1997

戈登遗传毒理学会议，1997 年

• 批准号: 2446343
• 负责人: LEONA D. SAMSON
• 金额: $ 1.15万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-06-09 至 1997-09-02
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2446343
• 关键词: DNA damage; DNA repair; gene mutation; meeting /conference /symposium; molecular genetics; neoplastic transformation; travel

DESCRIPTION: (Adapted from the Investigator's Abstract) Funds are requested in support of travel and/or registration costs for scientists attending the 1997 Gordon Research Conference on Genetic Toxicology. This bi-annual conference will be held at Colby-Sawyer College in New London, NH from June 22-27. Attendance at the conference has historically drawn participants from industry, academia, government research laboratories, and federal regulatory agencies from throughout the world. Session chairs, speakers, and discussion leaders are all experts in the fields of genetic toxicology, mutagenesis, carcinogenesis, DNA repair, or epidemiology. Genetic toxicology is a field dedicated to the identification of sources of genetic damage and to the definition of the mechanisms whereby such damage occurs. As such, the field of genetic toxicology necessarily relies upon data and insights drawn from a range of scientific disciplines. Sessions are designed to allow experts in these fields to discuss current results; and, time is provided for extensive discussions, both immediately following research presentations and in the discussion sessions. Finally, investigators of a few selected posters with results relevant to each session will be asked to make brief presentations (5 minute, 2-3 slides) during the discussion sessions. These presentations are intended to provide an opportunity for more broad conference participation, especially for students and postdoctoral fellows. The 1997 conference will extend our understanding of processes that impact genome stability especially following exposure to mutagens or carcinogens. Briefly, the sessions will address: 1) normal and aberrant DNA metabolism and replication; 2) normal and treatment mediated cellular responses to DNA damage; 3) applications of transgenic systems to the assessment of in vivo mutations; 4) molecular aspects of neoplastic transformation in the skin; 5) state-of-the-art techniques for the detection of DNA damage, gene mutations, or genomic instability, and 6) molecular evidence of the genetic effects in exposed human populations. Special lectures will be presented in the areas of DNA polymerase fidelity (T. Kunkel), biological consequences of DNA damage (B. Glickman), and factors influencing genomic instability (M. Radman). Such studies have direct relevance to the etiology of human cancer and to assessing the risk of newly induced germline mutations. Finally, the results and discussions anticipated at the Gordon Conference on Genetic Toxicology will provide a basis for more accurate estimates of the health risks of genotoxic agents and should provide data critical to the federal regulatory decisions concerning drug or chemical safety.

描述：（改编自研究者摘要）需要资金 支持参加会议的科学家的差旅和/或注册费用 1997年戈登遗传毒理学研究会议。 这一年两次的 会议将于6月在新罕布什尔州新伦敦的科尔比索耶学院举行 22-27. 出席会议历来吸引与会者 来自工业界、学术界、政府研究实验室和联邦 来自世界各地的监管机构。 会议主席，发言人， 讨论的领导者都是遗传毒理学领域的专家， 诱变、致癌、DNA修复或流行病学。 遗传 毒理学是一个致力于鉴定遗传物质来源的领域。 损害的定义和这种损害发生的机制。 因此，遗传毒理学领域必然依赖于数据和 来自一系列科学学科的见解。 会话 旨在让这些领域的专家讨论当前的结果;以及， 时间提供了广泛的讨论，无论是紧接着 研究报告和讨论会。 最后， 一些选定的海报的调查人员与每个相关的结果 会议将被要求做简短的演讲（5分钟，2-3张幻灯片） 在讨论会上。 这些介绍旨在提供 更广泛参与会议的机会，特别是 学生和博士后。 1997年的会议将扩大我们对影响人类的进程的理解， 基因组稳定性，尤其是暴露于诱变剂或致癌物后。 简要地说，会议将解决：1）正常和异常的DNA代谢 2）正常和治疗介导的细胞对DNA的反应 3）转基因系统在体内评估中的应用 突变; 4）皮肤中肿瘤转化的分子方面; 5） 检测DNA损伤，基因突变， 或基因组不稳定性，以及6）遗传效应的分子证据， 暴露的人群。 专题讲座将在以下领域进行： DNA聚合酶保真度（T. Kunkel），DNA的生物学后果 损坏（B. Glickman）和影响基因组不稳定性的因素（M. Radman）。 这类研究与人类癌症的病因学有直接关联 以及评估新诱导的生殖系突变的风险。 最后 戈登遗传学会议预期的结果和讨论 毒理学将为更准确地估计健康状况提供基础。 风险的遗传毒性剂，并应提供关键数据，以联邦 有关药物或化学品安全的监管决定。