2011 MAMMALIAN DNA REPAIR Gordon Research Conference

描述（由申请人提供）：本提案要求对一次关于哺乳动物DNA修复的国际会议提供部分支持，该会议是一次戈登研究会议，每两年举行一次，将于2011年2月6日至11日在加州文图拉举行。会议的广泛和长期目标是增加我们对多种DNA修复途径在人类健康中发挥的作用的理解，并促进进一步的研究。本次会议的具体目标将是召集约36位受邀发言人，代表哺乳动物DNA修复领域的关键领域，共有135名与会者在相对孤立的环境中参加为期五天的会议。该计划将有两个主题讲座和八个会议，广泛解决DNA修复，DNA损伤信号，重组和基因组稳定性，DNA和RNA碱基损伤修复，DNA修复在染色质的背景下，系统范围内的DNA损伤的反应，DNA修复在癌症病因学，癌症治疗，神经退行性变和衰老的作用的结构生物学的当前问题。此外，将有四个两个小时的海报会议，将允许所有参与者对这些和其他新出现的主题作出贡献。此外，将从海报摘要中选择10个简短的演讲，并在整个会议期间进行。这一应用的意义在于，戈登研究会议哺乳动物DNA修复是一个重要组成部分，推动研究人员在DNA修复的国际社会研究的大型和小型会议的旋转系列。本申请的健康相关性在于，演示和讨论将定义与人类健康和疾病相关的突出问题，特别是与癌症病因学、癌症治疗、神经变性和衰老相关的问题。 公共卫生相关性：该应用程序的健康相关性在于，在2011年哺乳动物DNA修复戈登研究会议上的演讲和讨论将有助于定义描述DNA修复如何影响人类健康和疾病的突出问题。特别是，它将有助于定义与癌症病因学，癌症治疗，神经退行性变和衰老有关的问题。

DESCRIPTION (provided by applicant): This proposal requests partial support for an international meeting on Mammalian DNA Repair, a Gordon Research Conference that is held bi-annually and will be held in Ventura, California, Feb 6-11, 2011. The broad and long term goal of the conference is to increase our understanding of, and stimulate further research on, the roles that a multitude of DNA Repair pathways play in human health. The specific aims of this meeting will be to convene ~36 invited speakers that represent critical areas in the mammalian DNA repair field, with a total of 135 participants for a five day conference in a relatively isolated setting. The program will have two Keynote Lectures and eight sessions that broadly address current issues in structural biology of DNA repair, DNA damage signaling, recombination and genomic stability, DNA and RNA base lesion repair, DNA repair in the context of chromatin, systems-wide responses to DNA damage, and the role of DNA repair in cancer etiology, cancer therapy, neurodegeneration and aging. In addition, there will be four two hour poster sessions that will permit all participants to contribute to these and other emerging topics. Moreover, 10 short talks will be chosen from the poster abstracts and sprinkled throughout the sessions. The significance of this application is that the Gordon Research Conference on Mammalian DNA Repair is a critical component the rotating series of large and small conferences that propel research in the international community of researchers in DNA Repair. The health relatedness of this application is that the presentations and discussions will define salient questions relating to human health and disease, in particular questions relating to cancer etiology, cancer treatment, neurodegeneration and aging. PUBLIC HEALTH RELEVANCE: Project Narrative The health relatedness of this application is that the presentations and discussions at the 2011 Mammalian DNA Repair Gordon Research Conference will help to define salient questions that delineate how DNA repair impacts human health and disease. In particular it will help define questions relating to cancer etiology, cancer treatment, neurodegeneration and aging.