ANTITUMOR ALKALOIDS VIA ITERATIVE REDUCTIVE ALKYLATION

通过迭代还原烷基化获得抗肿瘤生物碱

• 批准号: 2012334
• 负责人: THOMAS T SHAWE
• 金额: $ 6.33万
• 依托单位: BUCKNELL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-06-01 至 2002-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2012334
• 关键词: alkaloids; alkylation; antineoplastics; chemical cleavage; drug design /synthesis /production; indolizines; piperazines; reduction

DESCRIPTION: The long-term objective of this research project is to develop a particular organic synthetic method that shows significant promise as a means of preparing analogues of some well-known antitumor antibiotics. The project will focus on the preparation of analogues of quinocarcin, which has shown significant activity against a variety of solid mammalian carcinomas. The synthetic method utilizes a convergent approach that allows considerable variation in the structure of each component. After coupling these components, a one-pot procedure involving three distinct transformations produces the desired product without the isolation of any intermediates.

描述：本研究项目的长期目标是开发 一种特殊的有机合成方法， 制备一些众所周知的抗肿瘤抗生素的类似物的方法。 的 该项目将侧重于制备奎诺卡辛类似物， 显示出对多种实体哺乳动物癌的显著活性。 该合成方法利用了一种收敛方法， 每个组件的结构变化。 在将这些 组件，一锅程序，涉及三个不同的转换 产生所需产物而不分离任何中间体。