TYROSINE PHOSPHORYLATION & CELL SIGNALING

酪氨酰残基上的蛋白质磷酸化现在被认为是 是控制这种基本细胞的基本要素， 生长和增殖、分化、细胞骨架等过程 功能和细胞周期。 我们目前正在目睹一场 在结构、调节和功能方面取得进展的时期 蛋白酪氨酸激酶（PTKs）和蛋白酪氨酸磷酸酶 （PTPs），其协调作用控制细胞水平， 磷酸酪氨酸 关于“酪氨酸”的第三次会议的目标 磷酸化和细胞信号传导”的目的是提供一种形式， PTK和PTPs的研究将被整合，以帮助参与者了解如何 他们的结果有助于整个“大局”。“我们将组织 基于生理过程和细胞功能的课程， 而不是围绕特定类别的酶，以便尝试 提供一个生物学背景。 除了Ray Erikson和Sara的主题演讲之外， Courtneidge，所有发言者将从提交的摘要中选出。这 将允许重点放在鼓励研究生，博士后 和年轻的独立调查员来做演讲还应当 便于呈现最新和“最热”的结果。我们 预计将有300-350人出席，其中64人将进行口头演讲。 大约160人将展示海报。资金 这一建议将使更多的年轻研究人员， 参与，特别是那些没有独立资金的人。 我们希望在这次会议上整合PTK和PTPs的研究， 强调这些酶的生物学作用，将产生 一种凝聚力和跨领域的沟通感。

The phosphorylation of proteins on tyrosyl residues is now recognized to be an essential element in the control of such fundamental cellular processes as growth and proliferation, differentiation, cytoskeletaI function and the cell cycle. We are currently witnessing an outstanding period of progress in characterizing the structure, regulation and function of both protein tyrosine kinases (PTKs) and protein tyrosine phosphatases (PTPs), the coordinated action of which governs the levels of cellular phosphotyrosine. The objective of this Third Meeting on "Tyrosine Phosphorylation and Cellular Signaling" is to provide a format in which the study of PTKs and PTPs will be integrated to help participants see how their results contribute to the overall "big picture." We will organize the sessions based around physiological processes and cellular functions, rather than around particular categories of enzymes, so as to try and provide a biological context. With the exception of the Keynote Addresses by Ray Erikson and Sara Courtneidge, all speakers will be selected from submitted abstracts. This will allow emphasis to be placed on encouraging graduate students, postdocs and young independent investigators to present the talks. It also should facilitate the presentation of the most recent and "hottest" results. We anticipate an attendance of 300-350 of which 64 will give oral presentations and approximately 160 will present posters. The funds requested in this proposal will enable more young investigators to participate, especially those who do not yet have independent funding. We hope that the integration of research on PTKs and PTPs at this meeting, placing emphasis on the biological roles of these enzymes, will engender a sense of cohesiveness and communication across the field.