CSHL Meeting--Tyrosine Phosphorylation & cell Signalling

描述(由申请人提供) 蛋白质在酪氨酸残基上的磷酸化不被认为是一种 控制基本细胞过程的基本要素，如 生长和增殖、分化、细胞骨架功能和细胞 周而复始。我们目前正在见证在以下方面取得显著进展的时期 两种蛋白质酪氨酸的结构、调控和功能的表征 蛋白酪氨酸磷酸酶(PTPs)和蛋白酪氨酸磷酸酶(PTKs) 它的作用控制着细胞内磷酸酪氨酸的水平。目标是 第七次“酪氨酸磷酸化与细胞信号传递”会议纪要 提供了一种格式，以便将对PTK和PTP的研究整合到 帮助参与者了解他们的结果如何有助于整体的 我们将围绕生理过程组织会议。 和细胞功能，而不是围绕特定类别的酶， 从而试图提供一种生物学背景。 除了约瑟夫·施莱辛格和杰克的主旨演讲 迪克森，所有演讲者将从提交的摘要中选出。这将是 允许将重点放在鼓励研究生、博士后 和年轻的独立调查人员来介绍会谈。它也应该 便于展示最新和最热门的结果。我们 预计将有300-350人出席，其中60人将进行口头陈述 多达160人将展示海报。本提案中要求的资金将 让更多的年轻调查人员参与进来，特别是那些不参与的人 但仍有独立的资金来源。 我们希望在本次会议上整合关于PTK和PTP的研究， 强调这些酶的生物学作用将产生一种 在整个领域具有凝聚力和沟通能力。 随后的会议(2003年和2005年)将采用类似的形式，并将 包括与会议时间高度相关的主题。

DESCRIPTION (provided by applicant) The phosphorylation of proteins on tyrosyl residues is not recognized to be an essential element in the control of such fundamental cellular processes as growth and proliferation, differentiation, cytoskeletal function and the cell cycle. We are currently witnessing an outstanding period of progress in characterizing the structure, regulation and function of both protein tyrosine kinases (PTKs) and protein tyrosine phosphatases (PTPs), the coordinated action of which governs the levels of cellular phosphotyrosine. The objective of the Seventh Meeting on "Tyrosine Phosphorylation and Cellular Signalling" is provide a format in which the study of PTKs and PTPs will be integrated to help participants see how their results contribute to the overall "big Picture." We will organize the sessions based around physiological processes and cellular functions, rather than around particular categories of enzymes, so as to try and provide a biological context. With the exception of the Keynote Address by Joseph Schlessinger and Jack Dixon, all speakers will be selected from submitted abstracts. This will allow emphasis to be placed on encouraging graduate students, post doctorals and young independent investigators to present the talks. It also should facilitate the presentation of the most recent and "hottest" results. We anticipate an attendance of 300-350 of which -60 will give oral presentations and up to 160 will present posters. The funds requested in this proposal will enable more young investigators to participate, especially those who do not yet have independent funding. We hope that the integration of research on PTKs and PTPs at this meeting, placing emphasis on the biological roles of these enzymes, will engender a sense of cohesiveness and communication across the field. The subsequent meetings (2003 and 2005) will follow a similar format and will include topics that are highly relevant at the time of the meeting.