CSHL Meeting--Tyrosine Phosphorylation & cell Signalling

描述（由申请人提供） 酪氨酰残基上蛋白质的磷酸化不被认为是一种重要的酶。 控制基本细胞过程的基本要素， 生长和增殖，分化，细胞骨架功能和细胞 周期 我们目前正目睹在以下方面取得显著进展的时期： 表征蛋白质酪氨酸的结构、调节和功能 激酶（PTK）和蛋白酪氨酸磷酸酶（PTPs），协调的 其作用控制细胞磷酸酪氨酸的水平。 客观 第七届“酪氨酸磷酸化和细胞信号传导”会议 是提供一种格式，其中PTK和PTPs的研究将被整合， 帮助参与者了解他们的结果如何对整体“大 Picture.“我们将围绕生理过程组织会议 和细胞功能，而不是围绕特定类别的酶， 以便尝试提供生物学背景。 除了约瑟夫·施莱辛格和杰克的主题演讲外， 狄克逊，所有发言者将从提交的摘要中选出。 这将 重点鼓励研究生、博士后 和年轻的独立调查员来做演讲 还应当 便于呈现最新和“最热”的结果。 我们 预计将有300-350人出席，其中60人将作口头报告 多达160人将展示海报。 本提案所要求的资金将 让更多年轻的研究人员参与，特别是那些没有 有独立的资金来源。 我们希望在这次会议上整合PTK和PTPs的研究， 强调这些酶的生物学作用，将产生一个 凝聚力和跨领域沟通的感觉。 随后的会议（2003年和2005年）将采用类似的形式， 包括与会议召开时高度相关的议题。

DESCRIPTION (provided by applicant) The phosphorylation of proteins on tyrosyl residues is not recognized to be an essential element in the control of such fundamental cellular processes as growth and proliferation, differentiation, cytoskeletal function and the cell cycle. We are currently witnessing an outstanding period of progress in characterizing the structure, regulation and function of both protein tyrosine kinases (PTKs) and protein tyrosine phosphatases (PTPs), the coordinated action of which governs the levels of cellular phosphotyrosine. The objective of the Seventh Meeting on "Tyrosine Phosphorylation and Cellular Signalling" is provide a format in which the study of PTKs and PTPs will be integrated to help participants see how their results contribute to the overall "big Picture." We will organize the sessions based around physiological processes and cellular functions, rather than around particular categories of enzymes, so as to try and provide a biological context. With the exception of the Keynote Address by Joseph Schlessinger and Jack Dixon, all speakers will be selected from submitted abstracts. This will allow emphasis to be placed on encouraging graduate students, post doctorals and young independent investigators to present the talks. It also should facilitate the presentation of the most recent and "hottest" results. We anticipate an attendance of 300-350 of which -60 will give oral presentations and up to 160 will present posters. The funds requested in this proposal will enable more young investigators to participate, especially those who do not yet have independent funding. We hope that the integration of research on PTKs and PTPs at this meeting, placing emphasis on the biological roles of these enzymes, will engender a sense of cohesiveness and communication across the field. The subsequent meetings (2003 and 2005) will follow a similar format and will include topics that are highly relevant at the time of the meeting.