CSHL Meeting--Tyrosine Phosphorylation & cell Signalling

描述（由申请人提供） 蛋白质在酪氨酰残基上的磷酸化不被认为是一种 控制基本细胞过程的重要元素，例如 生长和增殖、分化、细胞骨架功能和细胞 循环。 我们目前正在见证一个显着进步的时期 表征蛋白质酪氨酸的结构、调节和功能 激酶（PTK）和蛋白酪氨酸磷酸酶（PTP），协调 其作用控制细胞磷酸酪氨酸的水平。 目标 第七次“酪氨酸磷酸化和细胞信号转导”会议 提供了一种格式，其中 PTK 和 PTP 的研究将被整合到 帮助参与者了解他们的结果如何对整体“大 图片。” 我们将根据生理过程组织会议 和细胞功能，而不是围绕特定类别的酶， 以便尝试提供生物学背景。 除了约瑟夫·施莱辛格和杰克的主题演讲 迪克森，所有演讲者都将从提交的摘要中选出。 这将 重点鼓励研究生、博士后 和年轻的独立调查员来演讲。 也应该 方便展示最新和“最热门”的结果。 我们 预计出席人数为 300-350 人，其中 -60 人将作口头报告 最多 160 人将展示海报。 本提案中要求的资金将 让更多的年轻研究者参与进来，特别是那些没有参与的年轻研究者 但有独立的资金。 我们希望在这次会议上整合PTKs和PTPs的研究， 强调这些酶的生物学作用，将产生 跨领域的凝聚力和沟通感。 随后的会议（2003 年和 2005 年）将遵循类似的形式，并将 包括与会议时高度相关的主题。

DESCRIPTION (provided by applicant) The phosphorylation of proteins on tyrosyl residues is not recognized to be an essential element in the control of such fundamental cellular processes as growth and proliferation, differentiation, cytoskeletal function and the cell cycle. We are currently witnessing an outstanding period of progress in characterizing the structure, regulation and function of both protein tyrosine kinases (PTKs) and protein tyrosine phosphatases (PTPs), the coordinated action of which governs the levels of cellular phosphotyrosine. The objective of the Seventh Meeting on "Tyrosine Phosphorylation and Cellular Signalling" is provide a format in which the study of PTKs and PTPs will be integrated to help participants see how their results contribute to the overall "big Picture." We will organize the sessions based around physiological processes and cellular functions, rather than around particular categories of enzymes, so as to try and provide a biological context. With the exception of the Keynote Address by Joseph Schlessinger and Jack Dixon, all speakers will be selected from submitted abstracts. This will allow emphasis to be placed on encouraging graduate students, post doctorals and young independent investigators to present the talks. It also should facilitate the presentation of the most recent and "hottest" results. We anticipate an attendance of 300-350 of which -60 will give oral presentations and up to 160 will present posters. The funds requested in this proposal will enable more young investigators to participate, especially those who do not yet have independent funding. We hope that the integration of research on PTKs and PTPs at this meeting, placing emphasis on the biological roles of these enzymes, will engender a sense of cohesiveness and communication across the field. The subsequent meetings (2003 and 2005) will follow a similar format and will include topics that are highly relevant at the time of the meeting.