CSHL Meeting--Tyrosine Phosphorylation & cell Signalling

CSHL会议--酪氨酸磷酸化

• 批准号: 6515137
• 负责人: NICHOLAS K TONKS
• 金额: $ 0.7万
• 依托单位: COLD SPRING HARBOR LABORATORY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-04-01 至 2006-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6515137
• 关键词: biological signal transduction; enzyme activity; enzyme induction /repression; meeting /conference /symposium; phosphorylation; protein tyrosine kinase; protein tyrosine phosphatase; travel; tyrosine

DESCRIPTION (provided by applicant) The phosphorylation of proteins on tyrosyl residues is not recognized to be an essential element in the control of such fundamental cellular processes as growth and proliferation, differentiation, cytoskeletal function and the cell cycle. We are currently witnessing an outstanding period of progress in characterizing the structure, regulation and function of both protein tyrosine kinases (PTKs) and protein tyrosine phosphatases (PTPs), the coordinated action of which governs the levels of cellular phosphotyrosine. The objective of the Seventh Meeting on "Tyrosine Phosphorylation and Cellular Signalling" is provide a format in which the study of PTKs and PTPs will be integrated to help participants see how their results contribute to the overall "big Picture." We will organize the sessions based around physiological processes and cellular functions, rather than around particular categories of enzymes, so as to try and provide a biological context. With the exception of the Keynote Address by Joseph Schlessinger and Jack Dixon, all speakers will be selected from submitted abstracts. This will allow emphasis to be placed on encouraging graduate students, post doctorals and young independent investigators to present the talks. It also should facilitate the presentation of the most recent and "hottest" results. We anticipate an attendance of 300-350 of which -60 will give oral presentations and up to 160 will present posters. The funds requested in this proposal will enable more young investigators to participate, especially those who do not yet have independent funding. We hope that the integration of research on PTKs and PTPs at this meeting, placing emphasis on the biological roles of these enzymes, will engender a sense of cohesiveness and communication across the field. The subsequent meetings (2003 and 2005) will follow a similar format and will include topics that are highly relevant at the time of the meeting.

描述（由申请人提供） 蛋白质在酪酶残基上的磷酸化不认为是 控制此类基本细胞过程的基本要素 生长和增殖，分化，细胞骨架功能和细胞 循环。 我们目前正在目睹取得的出色时期 表征两种蛋白酪氨酸的结构，调节和功能 激酶（PTK）和蛋白质酪氨酸磷酸酶（PTPS），协调 其作用控制了细胞磷酸酪氨酸的水平。 目标 关于“酪氨酸磷酸化和细胞信号传导”的第七次会议 提供了一种格式，其中PTK和PTP的研究将集成到 帮助参与者了解他们的结果如何促进总体“大 图片。“我们将基于生理过程组织会议 和细胞功能，而不是特定类别的酶， 为了尝试提供生物学背景。 除了约瑟夫·施莱辛格（Joseph Schlessinger）和杰克（Jack）的主题演讲外 Dixon，所有演讲者都将从提交的摘要中选择。 这会 允许强调鼓励研究生，邮政博士 和年轻的独立调查员提出了谈判。 也应该 促进呈现最新和“最热门”的结果。 我们 预计出席人数为300-350，其中-60将进行口头介绍 最多可达160个海报。 本提案中要求的资金将 使更多的年轻调查人员参与，尤其是那些不参加 但是有独立的资金。 我们希望在这次会议上对PTK和PTP的研究整合， 强调这些酶的生物学作用，将产生 整个领域的凝聚力和沟通感。 随后的会议（2003年和2005年）将遵循类似的格式，将 包括会议时高度相关的主题。