ST LOUIS BREAST TISSUE REGISTRY

圣路易斯乳腺组织登记处

• 批准号: 2104214
• 负责人: HELEN R DONIS-KELLER
• 金额: $ 28.45万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-09-30 至 1997-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2104214
• 关键词: automated medical record system; biomarker; breast neoplasms; cancer registry /resource; female; genetic markers; human tissue; longitudinal human study; neoplasm /cancer classification /staging; pathology; prognosis; tissue resource /registry

One of the objectives of the pathologic examination of breast carcinoma tissue is to predict the future course of the disease and even to predict the form of therapy that will be effective. For many cases the prognosis is too general and the best therapy is unknown. The development of new tumor markers and the thorough testing of existing ones offer real promise for identifying reliable prognostic indicators; however, progress has been hindered by the lack of an adequate supply of tumor tissue from patients with known outcome. The availability of archived breast tumor tissue in paraffin blocks, combined with follow-up data on patients, would provide a significant clinical resource for tumor marker studies. The purpose of this project is to provide such a resource. We propose to establish the St.Louis Breast Tissue Registry, which will provide unstained paraffin sections, from well-defined subsets of breast carcinoma, to investigators who plan to study the prognostic significance of various tumor markers. The Registry will consist of a consortium of 1 private practice and 7 hospital-based groups who have agreed to pool their resources and create a registry of paraffin-embedded breast tumor specimens for which significant follow-up information exists. Pathologists at the collaborating institutions will supply the paraffin blocks, and their respective tumor registries will supply the follow-up data. We expect to collect and process for distribution to investigators a minimum of 8000 samples of breast cancer tissue. The tumor samples include 507 cases (estimated) of ductal carcinoma in-situ, and 2,535 cases (estimated) of node-negative breast carcinoma. All the information relating to the tumor specimens and patient follow-up will be entered into a computerized central database (using the Gemstone/Geode object-oriented database management system) located at the Washington University School of Medicine. The St. Louis Breast Tissue Registry will cooperate with similar registries in the United States and with the National Institutes of Health to form a consortium of registries with uniform policies and operations. We expect that the tumor marker data collected on specimens from these cases will significantly advance our ability to predict outcome and will lead to improved therapy for patients with breast cancer.

乳腺癌病理检查的目的之一 组织是用来预测疾病的未来进程，甚至是预测 有效的治疗形式。对于许多病例来说，预后 太笼统了，最好的治疗方法是未知的。新技术的发展 肿瘤标记物和对现有标记物的彻底检测提供了真正的希望 确定可靠的预测指标；然而，已经取得了进展 因患者缺乏足够的肿瘤组织供应而受阻 结果已知。年存档的乳腺肿瘤组织的可用性 石蜡切片，结合患者的随访数据，将提供 是肿瘤标记物研究的重要临床资源。目的 这个项目就是为了提供这样的资源。我们建议设立 圣路易斯乳房组织登记处，将提供未染色的石蜡 切片，从定义明确的乳腺癌亚群到研究人员 世卫组织计划研究各种肿瘤标志物的预后意义。 注册处将由一个由1家私人执业律师和7家私人执业律师组成的财团组成。 以医院为基础的团体同意集中他们的资源并创造 石蜡包埋乳腺肿瘤标本登记表 存在重要的后续信息。这所大学的病理学家 合作机构将提供石蜡块，以及他们的 各自的肿瘤登记机构将提供后续数据。我们希望 收集和处理至少8000份分发给调查人员 乳腺癌组织样本。肿瘤标本包括507例 (估计)导管原位癌，以及2535例(估计) 结节阴性的乳腺癌。所有与肿瘤有关的信息 标本和患者的随访将输入一个计算机化的 中央数据库(使用Gemstone/Geode面向对象数据库 管理系统)位于华盛顿大学管理学院 医学。圣路易斯乳房组织登记处将与类似的 美国和美国国立卫生研究院的登记处 组成一个拥有统一政策和业务的登记处联盟。 我们预计从这些样本中收集的肿瘤标记物数据 病例将显著提高我们预测结果和意志的能力 使乳腺癌患者的治疗方法得到改进。