Targeting the genome and epigenome of the exercising skeletal muscle

针对运动骨骼肌的基因组和表观基因组

• 批准号: DP190103081
• 负责人: Prof Nir Eynon
• 金额: $ 21.32万
• 依托单位: Victoria University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-01-01 至 2022-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP190103081
• 关键词: Targeting; genome; epigenome; exercising; skeletal

This project aims is to discover epigenetic and genetic biomarkers that predict fitness changes, following exercise intervention. Individuals are remarkably variable in their responses to exercise interventions, and a large portion of these responses is attributed to genetics, and epigenetics (the effect of the environment on the expression of genes). Using controlled exercise training as a model, this project expects to discover epigenetic and genomic markers in skeletal muscle predictive of exercise adaptations. This will contribute to the development and future delivery of targeted and personalised exercise programs for the general population. This has important implications for improving health in the Australian population.

该项目旨在发现预测运动干预后健身变化的表观遗传和遗传生物标志物。个体对运动干预的反应是显著可变的，这些反应的很大一部分归因于遗传学和表观遗传学（环境对基因表达的影响）。本项目以控制性运动训练为模型，期望在骨骼肌中发现可预测运动适应的表观遗传和基因组标记。这将有助于为普通人群制定和提供有针对性的个性化锻炼计划。这对改善澳大利亚人口的健康状况具有重要意义。