POPULATION BASED CASE CONTROL STUDY OF ORAL CANCER

基于人群的口腔癌病例对照研究

• 批准号: 2545642
• 负责人: Maria Rosa WATSON
• 金额: $ 8.61万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-09-30 至 2001-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2545642
• 关键词: Hispanic Americans; cancer risk; caucasian American; clinical research; early diagnosis; human mortality; human population study; human subject; interview; medical outreach /case finding; method development; neoplasm /cancer epidemiology; oral pharyngeal neoplasm; racial /ethnic difference; statistics /biometry

DESCRIPTION: This application requests a Mentored Clinical Scientist Development Award (MCSDA) to support the pursuit of a doctoral program in epidemiology (DrPH) while remaining a part-time dental faculty member. The plan of study consists of a five-year program of integrated training in clinical epidemiology that is oriented towards oral health issues in minority populations. The proposed program will enable Dr. Maria Rosa Watson to establish an independent clinical and research faculty position at the University of Maryland at Baltimore Dental School. The academic and research environment for the doctoral degree will be centered at the Department of Epidemiology, Johns Hopkins University School of Public Health (JHU-SPH). The primary mentor, Dr. Watson will aslo collaborate with other investigators at the University of Maryland at Baltimore Dental School. Dr. Watson's faculty development mentor will be Dr. James Rule, the Chairman of the Department of Pediatric Dentistry at UMAB-DS, who will supervise her pedagogical training by coordinating her clinical and teaching opportunities. This program proposes to focus on general skills and knowledge in epidemiology as well as on important minority oral health research issues, including: 1) techniques for obtaining adequate samples of minority populations; 2) development of culturally appropriate instruments; and 3) techniques for validating survey instruments. The course work described is a typical intensive two years of course work in epidemiology and biostatistics, followed by comprehensive examinations over the first two years. The doctoral thesis research follows in year 02, supplemented in years 01-05 with complementary research and teaching activities. The specific research plan proposed includes two studies, 1. and analysis of the determinants of survival in Hispanics compared to to others; and 2. a population-based case-control study of risk factors for oral cancer in Hispanics. The specific aims of the study are: 1) to assess the risk factors for oral cancer (e.g., diet, tobacco, alcohol, and other cultural practices) between Hispanics and Whites; 2) to determine and compare oral cancer survival and mortality rates between Hispanics and Whites; and 3) to evaluate the relationship between lack of early screenings, low level of oral cancer knowledge and oral cancer mortality rates. The proposed design is a case-control study utilizing cases from the New Mexico Tumor Registry. Controls will be selected by Random Digit Dialing (RDD). Interviews will be conducted by phone by experienced interviewers from the New Mexico Tumor Registry, using a structured questionnaire that will be specifically designed for this study. The proposed research project will enhance the understanding of the descriptive epidemiology and etiology of oral cancer, in particular as it pertains to incidence, prevalence, survival, and specific mortality and risk factors in minority populations.

描述：本申请要求一名指导临床科学家 发展奖（MCSDA），以支持博士课程的追求， 流行病学（DrPH），同时保持兼职牙科教员。 学习计划包括一个五年的综合培训计划 在临床流行病学，是面向口腔健康问题， 少数民族人口。 该计划将使玛丽亚·罗莎博士 沃森建立一个独立的临床和研究教师的立场 在马里兰州大学的巴尔的摩牙科学校。 博士学位的学术和研究环境将是 在约翰霍普金斯大学流行病学系 公共卫生学院（JHU-SPH）。 主要导师沃森博士将 他与马里兰州大学的其他研究人员合作， 巴尔的摩牙科学校。 沃森博士的教师发展导师将是 博士詹姆斯·鲁尔，儿科牙科系主任， UMAB-DS，负责监督她的教学培训， 临床和教学机会。 该计划建议专注于一般技能和知识， 流行病学以及重要的少数民族口腔健康研究问题， 包括：1）获得少数群体适当样本的技术 （2）制定文化上适当的文书;（3） 验证测量仪器的技术。 课程工作描述 是流行病学中典型的两年密集课程， 生物统计学，然后是前两个全面的考试 年 博士论文研究如下02年，补充在 年01-05与互补的研究和教学活动。 提出的具体研究计划包括两项研究，1。 和分析 与其他人相比，西班牙裔人生存的决定因素; 2. 中国人群口腔癌危险因素的病例对照研究 西班牙裔 研究的具体目的是：1）评估风险 口腔癌的因素（例如，饮食、烟草、酒精和其他文化 西班牙裔和白人之间的做法）; 2）确定和比较口头 西班牙裔和白人之间的癌症存活率和死亡率;以及3） 评估缺乏早期筛查、低水平 口腔癌知识和口腔癌死亡率的关系。 拟议 设计是一项病例对照研究，利用来自新墨西哥州肿瘤的病例 注册表 将通过随机数字拨号（RDD）选择控件。 面试将由经验丰富的访问员以电话方式进行， 新墨西哥州肿瘤登记处，使用结构化问卷， 专门为这项研究设计的。 拟议的研究项目将 加强对描述性流行病学和病原学的理解， 口腔癌，特别是它涉及的发病率，患病率， 少数群体的生存率、具体死亡率和风险因素。