REGULATION OF ACINAR CELL PROLIFERATION

描述(改编自《调查员摘要》)：现在 提案继续这位调查员正在进行的努力，以澄清 β-1，4-半乳糖基转移酶(GalTase)的生物学效应 腺泡细胞生长反应中GTA-K的表达以下是具体的 人们提出的目标是：(1)阐明红豆杉的染色体结构 GTA-K和确定调控序列在表达中的作用 这种蛋白质的。(2)研究GTA-K的生物学效应。 不同功能结构域的定点突变。这是意料之中的 这些研究将为一种可能的机制提供新的信息 参与腺泡细胞生长的调节。一种已经成为 近三十年来，被广泛用于研究腺泡细胞生长的是 腺泡细胞对β-肾上腺素能刺激的反应。这 研究的目的是进一步描述与以下相关的机制 这一扩散事件。

DESCRIPTION (Adapted from the investigator's Abstract): The present proposal continues the ongoing efforts of this investigator to elucidate the biological effects of beta 1,4-galactosyltransferase (Gal Tase), and the expression of GTA-K on acinar cell growth response. The following specific aims have been proposed: (1) Elucidate the chromosomal structure of the GTA-K and determine the role of the regulatory sequences in the expression of this protein. (2) To study the biological effects of the GTA-K through site-directed mutagenesis of various functional domains. It is anticipated that these studies will provide new information about one possible mechanism involved in the regulation of acinar cell growth. A model which has been widely used, for almost three decades, to study acinar cell growth is the acinar cell proliferation in response to beta adrenergic stimulation. This study is aimed towards further characterizing the mechanisms associated with this proliferative event.