REGULATION OF ACINAR CELL PROLIFERATION

描述（改编自研究者摘要）：目前 该提案继续了本研究人员正在进行的努力，以阐明 β 1，4-半乳糖基转移酶（Gal Tase）的生物学效应，以及 GTA-K表达对腺泡细胞生长的反应。 以下具体 目的是：（1）阐明该物种的染色体结构， GTA-K的表达，并确定调控序列的作用， 这种蛋白质。 (2)为了研究GTA-K的生物效应， 各种功能结构域的定点诱变。 预计 这些研究将提供关于一种可能机制的新信息 参与腺泡细胞生长的调节。 一个模型， 近三十年来，广泛用于研究腺泡细胞生长的是 腺泡细胞增殖对β肾上腺素能刺激的反应。 这 研究旨在进一步表征与以下相关的机制： 这个增殖事件。

DESCRIPTION (Adapted from the investigator's Abstract): The present proposal continues the ongoing efforts of this investigator to elucidate the biological effects of beta 1,4-galactosyltransferase (Gal Tase), and the expression of GTA-K on acinar cell growth response. The following specific aims have been proposed: (1) Elucidate the chromosomal structure of the GTA-K and determine the role of the regulatory sequences in the expression of this protein. (2) To study the biological effects of the GTA-K through site-directed mutagenesis of various functional domains. It is anticipated that these studies will provide new information about one possible mechanism involved in the regulation of acinar cell growth. A model which has been widely used, for almost three decades, to study acinar cell growth is the acinar cell proliferation in response to beta adrenergic stimulation. This study is aimed towards further characterizing the mechanisms associated with this proliferative event.