FACTOR EFFECTS ON ORAL COMPLICATIONS OF DIABETES

对糖尿病口腔并发症的影响因素

• 批准号: 6379945
• 负责人: MICHAEL G HUMPHREYS-BEHER
• 金额: $ 22.15万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-30 至 2003-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6379945
• 关键词: NOD mouse; clinical research; diabetes mellitus; enzyme linked immunosorbent assay; epidermal growth factor; growth factor; histology; homeostasis; human subject; insulin; insulinlike growth factor; medical complication; neurotrophic factors; oral health; periodontium disorder; radioimmunoassay; saliva; serum; transforming growth factors; wound healing

DESCRIPTION: The salivary glands are a major source of several factors, which play important roles in both oral and systemic organ homeostasis and wound healing. The roles of these factors, which include IGF-I, IGF-II, NGF, TGF alpha and beta, and EGF, has been well-studied. However, the fact that the salivary glands appear to be a major source of these growth factors present a interesting question both in the primary route of reentry into the system and the relative importance of these salivary- derived proteins systemically. In diabetic patients both (Type I and II) a major disease complication is diminished capacity of wound healing and in the oral cavity increased periodontal disease. A similar picture occurs in animal models of diabetes in there is also a progressive loss of growth factors from saliva in accordance with diabetes onset. Therefore, the investigators propose to look for the potential loss of salivary-derived growth factors associated with the observed decrease in wound healing capacity in diabetic patients. To accomplish this goal, they first plan to use the diabetic patient base of the University of Florida to investigate the changes in growth factor levels in patient saliva and serum after surgical procedures, as compared to healthy non-diabetic individuals undergoing similar procedures. Second, they intend to determine the influence of changes in growth factor levels in saliva on wound healing in the NOD mouse model for IDDM. With this, they intend to establish the NOD mouse as a viable model for this aspect of the disease and then to be able to employ this model to more thoroughly investigate the impact of decreased levels of salivary growth factors on experimentally introduced soft and hard tissue injuries. The results of these studies should elucidate the importance of salivary-derived growth factors on systemic homeostasis and wound repair and potentially provide insight into the viability of replacement strategies to combat several complications of human diabetes which may involve an underlying deficiency in wound repair mechanisms.

描述：唾液腺是几种因子的主要来源， 它们在口腔和全身器官的动态平衡和 伤口愈合。这些因素的作用，包括IGF-I，IGF-II， NGF、转化生长因子α、β转化生长因子和表皮生长因子已经得到了很好的研究。然而，事实是 唾液腺似乎是这些生长的主要来源 因素提出了一个有趣的问题，这两个主要途径 以及这些唾液的相对重要性- 系统地衍生蛋白质。糖尿病患者(I型和II型) 一种主要的疾病并发症是伤口愈合能力减弱和 在口腔中增加了牙周病。类似的情况也发生了 在糖尿病的动物模型中，还有一种渐进性的生长丧失 来自唾液的因素与糖尿病的发病有关。因此， 研究人员建议寻找唾液来源的潜在损失 与观察到的伤口愈合率下降有关的生长因子 糖尿病患者的能力。为了实现这一目标，他们首先计划 利用佛罗里达大学的糖尿病患者基础进行调查 治疗前后患者唾液和血清中生长因子水平的变化 与健康的非糖尿病人相比，外科手术 正在经历类似的程序。其次，他们打算确定 唾液中生长因子水平的变化对创面愈合的影响 IDDM的点头鼠模型。有了这一点，他们打算建立点头 小鼠作为这方面疾病的可行模型，然后能够 要使用此模型来更彻底地调查 实验引入的唾液生长因子水平降低 软硬组织损伤。这些研究的结果应该是 阐明唾液源生长因子在系统性红斑狼疮中的重要性 动态平衡和伤口修复，并潜在地提供了对 替代战略的可行性，以对抗几种并发症 人类糖尿病，可能涉及伤口修复的潜在缺陷 机制。