REGULATION OF ACINAR CELL PROLIFERATION

腺泡细胞增殖的调节

• 批准号: 2897005
• 负责人: MICHAEL G HUMPHREYS-BEHER
• 金额: $ 19.95万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-08-01 至 2001-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2897005
• 关键词: acinar cell; active sites; antisense nucleic acid; beta adrenergic receptor kinase; calmodulin dependent protein kinase; cell growth regulation; cell proliferation; enzyme mechanism; epidermal growth factor; galactosyltransferases; gene expression; genetic library; genetic regulatory element; isoproterenol; laboratory mouse; laboratory rat; molecular cloning; parotid gland; protein tyrosine kinase; reporter genes; site directed mutagenesis; transcription factor; transfection

DESCRIPTION (Adapted from the investigator's Abstract): The present proposal continues the ongoing efforts of this investigator to elucidate the biological effects of beta 1,4-galactosyltransferase (Gal Tase), and the expression of GTA-K on acinar cell growth response. The following specific aims have been proposed: (1) Elucidate the chromosomal structure of the GTA-K and determine the role of the regulatory sequences in the expression of this protein. (2) To study the biological effects of the GTA-K through site-directed mutagenesis of various functional domains. It is anticipated that these studies will provide new information about one possible mechanism involved in the regulation of acinar cell growth. A model which has been widely used, for almost three decades, to study acinar cell growth is the acinar cell proliferation in response to beta adrenergic stimulation. This study is aimed towards further characterizing the mechanisms associated with this proliferative event.

描述（改编自研究者摘要）：目前 该提案继续了本研究人员正在进行的努力，以阐明 β 1，4-半乳糖基转移酶（Gal Tase）的生物学效应，以及 GTA-K表达对腺泡细胞生长的反应。 以下具体 目的是：（1）阐明该物种的染色体结构， GTA-K的表达，并确定调控序列的作用， 这种蛋白质。 (2)通过研究GTA-K的生物学效应 各种功能结构域的定点诱变。 预计 这些研究将提供关于一种可能机制的新信息 参与腺泡细胞生长的调节。 一个模型， 近三十年来，广泛用于研究腺泡细胞生长的是 腺泡细胞增殖对β肾上腺素能刺激的反应。 这 研究旨在进一步表征与以下相关的机制： 这个增殖事件。

项目成果

Desipramine changes salivary gland function, oral microbiota, and oral health in rats.

地昔帕明改变大鼠的唾液腺功能、口腔微生物群和口腔健康。

• DOI: 10.1016/s0014-2999(00)00770-6
• 发表时间: 2000
• 期刊: European journal of pharmacology
• 影响因子: 5
• 作者: Koller,MM;Maeda,N;Scarpace,PJ;Humphreys-Beher,MG
• 通讯作者: Humphreys-Beher,MG

Cell surface galactosyltransferase acts as a general modulator of rat acinar cell proliferation.

细胞表面半乳糖基转移酶充当大鼠腺泡细胞增殖的一般调节剂。

• DOI: 10.1007/bf00219524
• 发表时间: 1990
• 期刊: Molecular and cellular biochemistry
• 影响因子: 4.3
• 作者: Humphreys-Beher,MG;Zelles,T;Maeda,N;Purushotham,KR;Schneyer,CA
• 通讯作者: Schneyer,CA

Rat parotid gland acinar cell proliferation: signal transduction at the plasma membrane.

大鼠腮腺腺泡细胞增殖：质膜的信号转导。

• DOI: 10.1177/10454411930040034001
• 发表时间: 1993
• 期刊: Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists
• 作者: Purushotham,KR;Nakagawa,Y;Humphreys-Beher,MG;Maeda,N;Schneyer,CA
• 通讯作者: Schneyer,CA

Inhibition of rat parotid gland growth response induced by chronic isoproterenol following treatment with quinolone antibiotics.

喹诺酮类抗生素治疗后慢性异丙肾上腺素诱导的大鼠腮腺生长反应的抑制。

• DOI: 10.1007/bf00229745
• 发表时间: 1996
• 期刊: Molecular and cellular biochemistry
• 影响因子: 4.3
• 作者: Kelentey,B;Kerr,M;Tao,Z;Purushotham,KR;Humphreys-Beher,MG;Zelles,T
• 通讯作者: Zelles,T

Desipramine induced changes in salivary proteins, cultivable oral microbiota and gingival health in aging female NIA Fischer 344 rats.

地昔帕明诱导老年雌性 NIA Fischer 344 大鼠唾液蛋白、可培养口腔微生物群和牙龈健康的变化。

• DOI: 10.1016/s0024-3205(00)00951-6
• 发表时间: 2000
• 期刊: Life sciences
• 影响因子: 6.1
• 作者: Koller,MM;Purushotham,KR;Maeda,N;Scarpace,PJ;Humphreys-Beher,MG
• 通讯作者: Humphreys-Beher,MG