PSYCHOBIOLOGY OF EATING BEHAVIOR IN EATING DISORDERS

描述（改编自申请人的摘要）：神经性贪食症是一种 严重的饮食失调，其特征是经常失控 暴饮暴食 暴饮暴食症是一种最近被描述的疾病 这种疾病主要发生在肥胖的人身上， 严重的发病率。 虽然人们对这一点了解很多， 这些疾病的特点和治疗，特别是贪食症 然而，对它们的病理生理学的了解仍然有限。 这项正在进行的研究计划的目的是严格描述 暴食症患者的饮食行为， 这些信息，以生成和测试有关他们的假设 病理生理学 迄今为止的研究表明，神经性贪食症患者有一个 在饱腹感的感知障碍，这是最明显的，在后来的 暴饮暴食的阶段。 此外，最近的研究表明， 这种综合征的患者表现为胃排空减慢， 餐后CCK释放。 这些发现现在足以表明 神经性贪食症病理生理学模型和拟议项目 将严格测试该模型的重要特性。 一个实验将 检验餐后CCK释放减弱是由以下原因引起的假设： 胃排空延迟。 第二个生物实验，基于报告 在神经性贪食症的胃容量增加，将检查胃 功能，并将评估他们对胃的感觉， 胃扩张和对进餐的反射性胃舒张反应。 本研究 还将解决神经性贪食症疼痛阈值升高的报告， 并使用信号检测理论的方法来测量感知灵敏度 以及对胃扩张和热刺激的反应偏差。 这将 确定神经性贪食症的饱腹感障碍是否是 更普遍的感觉障碍

DESCRIPTION (Adapted from the Applicant's Abstract): Bulimia Nervosa is a serious eating disorder which is characterized by frequent uncontrolled eating binges. Binge Eating Disorder is a more recently described disorder which occurs primarily in obese individuals and which also carries significant morbidity. While a great deal is known about the characteristics and treatment of these disorders, particularly Bulimia Nervosa, there is as yet a limited understanding of their pathophysiology. The aim of this ongoing research program has been to rigorously describe the eating behavior of individuals with disorders of binge eating and, using this information, to generate and test hypotheses concerning their pathophysiology. Work to date has suggested that patients with Bulimia Nervosa have a disturbance in the perception of satiety which is most apparent in the later stages of the binge meal. In addition, recent studies indicate that patients with this syndrome display slowed gastric emptying and blunted postprandial CCK release. These findings are now sufficient to suggest a model of the pathophysiology of Bulimia Nervosa, and the proposed project will critically test important features of this model. One experiment will test the hypothesis that blunted postprandial CCK release is cause by delayed gastric emptying. A second biological experiment, based on reports of increased gastric capacity in Bulimia Nervosa, will examine gastric function in these patients and will assess their perception of gastric distention and reflex gastric relaxation response to a meal. This study will also address reports of elevated pain thresholds in Bulimia Nervosa, and use methods of signal detection theory to measure perceptual sensitivity and response bias to gastric distention, and thermal stimuli. This will establish whether the disturbance in satiety in Bulimia Nervosa is part of a more general sensory disturbance.