RISK FACTORS FOR ANOREXIA NERVOSA

描述（申请人的摘要）：这是一个小赠款的修订 申请最初于1996年9月提交。 神经性厌食症是一种严重的，有时是致命的精神疾病， 病因不明。 它往往与严重损害有关， 功能的全面性。 它通常是慢性的，对 治疗 共识是，许多因素有助于 厌食症的病因 已经进行了研究， 的临床表现和疾病的过程;然而，鉴于 相对较低的患病率和这种疾病的复杂性， 对使妇女处于危险之中的两个因素的了解非常有限， 发展中的神经性厌食症和具体的治疗效果 方式。 拟议的研究将使用结构化的临床访谈，评估 一系列假定的饮食失调风险因素，包括厌食症 神经。 这项研究将为制定一项 神经性厌食症累积风险的经验模型。 研究 将确定神经性厌食症的具体和一般风险因素。 在 此外，我们将能够在多大程度上解决已识别的风险 因素在确定治疗结果方面具有预测价值， 我们的受试者将是寻求治疗的个人， 一个长期的时期 该研究的次要目标是比较风险 神经性厌食症与其他饮食失调的因素。 新英格兰 妇女健康项目正在从诊所和社区病例中收集数据， 患有暴食症和神经性贪食症的女性。 虽然这些都是 完全独立的项目，两项研究采用相同的评估 新英格兰妇女健康项目的程序和数据集将 可以进行这样的比较。 本研究的最后一个次要目的是 比较神经性厌食症两种亚型的危险因素。 这项研究的结果将有助于建立一个更坚实的 关于神经性厌食症病因的经验基础。 通过 研究了大量的风险因素，这项研究将提供 关于各种因素的相对重要性的重要信息 假定的危险因素。 这些数据将有助于未来的前瞻性研究 通过缩小和集中这种调查，使其可行。 最后，这些数据将为今后的预防和早期干预工作提供信息。 干预 鉴于神经性厌食症的严重性及其对 治疗，这些干预措施可能会改善，以有效减少 神经性厌食症的发病率，如果他们针对那些高 基于已识别的风险因素。

DESCRIPTION (Applicant's Abstract): This is a revision of a small grant application originally submitted in September, 1996. Anorexia nervosa is a serious and sometimes fatal psychiatric disorder of unknown etiology. It is often associated with significant impairment across the full range of functioning. It is often chronic and resistant to treatment. Consensus is that a multitude of factors contribute to the etiology of anorexia. Studies have been conducted which provide description of the clinical presentation and course of the disorder; however, given the relatively low prevalence rate and the complexity of this disorder, there is very limited knowledge of both the factors which put women at risk for developing anorexia nervosa and the efficacy of specific treatment modalities. The proposed study will use a structured clinical interview which assesses a range of putative risk factors for eating disorders, including anorexia nervosa. The study will contribute important data for developing an empirically based model of cumulative risks for anorexia nervosa. The study will identify specific and general risk factors for anorexia nervosa. In addition, we will be able to address the extent to which the identified risk factors have predictive value in determining treatment outcome given that our subjects will be treatment seeking individuals who will be followed for a long-term period. A secondary goal of the study is to compare the risk factors for anorexia nervosa with other eating disorders. The New a England Women s Health Project is collecting data from clinic and community cases of women with binge eating disorder and bulimia nervosa. Although these are completely independent projects, the two studies employ identical assessment procedures and the data set from the New England Women s Health Project will be available for such comparisons. A final secondary aim of the study is to compare the risk factors for the two subtypes of anorexia nervosa. The results from this study will contribute to building a more solid empirical foundation regarding the etiology of anorexia nervosa. By examining a large number of risk factors in unison, this study will provide important information regarding the relative significance of various putative risk factors. Such data will facilitate future prospective studies by narrowing and focusing such an investigation so as to make it feasible. Finally, these data will inform future efforts aimed at prevention and early intervention. Given the severity of anorexia nervosa and its resistance to treatment, such interventions may improve to be effective in reducing the rates of anorexia nervosa if they target those individuals who are at high risk based on identified risk factors.