RISK FACTORS FOR ANOREXIA NERVOSA

描述(申请人摘要)：这是对一项小额资助的修订 最初于1996年9月提交的申请。 神经性厌食症是一种严重的，有时甚至是致命的精神疾病 病因不明。它通常与以下方面的重大损害有关 功能齐全。它通常是慢性的，并对 治疗。人们的共识是，有多种因素导致了 厌食症的病因。已经进行的研究提供了描述 疾病的临床表现和病程；然而，鉴于 相对较低的患病率和这种疾病的复杂性，有 对这两个将女性置于危险之中的因素的了解非常有限 神经性厌食症的发生和特定治疗的疗效 医疗模式。 这项拟议的研究将使用结构化的临床访谈，评估 饮食失调的一系列可能的危险因素，包括厌食症 神经质。这项研究将为开发一种 神经性厌食症累积风险的经验模型。这项研究 将确定神经性厌食症的具体和一般风险因素。在……里面 此外，我们将能够解决已确定的风险的程度 考虑到这些因素在决定治疗结果方面具有预测价值 我们的主题将是寻求治疗的个人，他们将被跟踪 一个长期的时期。这项研究的次要目标是比较风险 神经性厌食症与其他进食障碍的因素。新英格兰 女性S健康项目正在从临床和社区病例中收集数据 患有暴饮暴食障碍和神经性暴食症的女性。尽管这些都是 完全独立的项目，这两项研究采用相同的评估 新英格兰妇女S健康项目的程序和数据集将 可以进行这样的比较。该研究的最后一个次要目标是 比较两种亚型神经性厌食症的危险因素。 这项研究的结果将有助于建立一个更坚实的 神经性厌食症病因学的经验基础。通过 这项研究一致地检查了大量的风险因素，将提供 关于不同组织的相对重要性的重要信息 假定的风险因素。这些数据将为未来的前瞻性研究提供便利 通过缩小范围和重点进行这样的调查，以使其可行。 最后，这些数据将为今后旨在预防和及早采取行动提供信息。 干预。鉴于神经性厌食症的严重性及其对 治疗，这样的干预措施可能会改善，以有效地减少 如果他们针对那些处于高厌食症状态的人，神经性厌食症的发生率 基于已识别的风险因素的风险。

DESCRIPTION (Applicant's Abstract): This is a revision of a small grant application originally submitted in September, 1996. Anorexia nervosa is a serious and sometimes fatal psychiatric disorder of unknown etiology. It is often associated with significant impairment across the full range of functioning. It is often chronic and resistant to treatment. Consensus is that a multitude of factors contribute to the etiology of anorexia. Studies have been conducted which provide description of the clinical presentation and course of the disorder; however, given the relatively low prevalence rate and the complexity of this disorder, there is very limited knowledge of both the factors which put women at risk for developing anorexia nervosa and the efficacy of specific treatment modalities. The proposed study will use a structured clinical interview which assesses a range of putative risk factors for eating disorders, including anorexia nervosa. The study will contribute important data for developing an empirically based model of cumulative risks for anorexia nervosa. The study will identify specific and general risk factors for anorexia nervosa. In addition, we will be able to address the extent to which the identified risk factors have predictive value in determining treatment outcome given that our subjects will be treatment seeking individuals who will be followed for a long-term period. A secondary goal of the study is to compare the risk factors for anorexia nervosa with other eating disorders. The New a England Women s Health Project is collecting data from clinic and community cases of women with binge eating disorder and bulimia nervosa. Although these are completely independent projects, the two studies employ identical assessment procedures and the data set from the New England Women s Health Project will be available for such comparisons. A final secondary aim of the study is to compare the risk factors for the two subtypes of anorexia nervosa. The results from this study will contribute to building a more solid empirical foundation regarding the etiology of anorexia nervosa. By examining a large number of risk factors in unison, this study will provide important information regarding the relative significance of various putative risk factors. Such data will facilitate future prospective studies by narrowing and focusing such an investigation so as to make it feasible. Finally, these data will inform future efforts aimed at prevention and early intervention. Given the severity of anorexia nervosa and its resistance to treatment, such interventions may improve to be effective in reducing the rates of anorexia nervosa if they target those individuals who are at high risk based on identified risk factors.