AURICULAR ACUPUNCTURE EFFECT ON COCAINE CRAVING

耳针对可卡因渴望的影响

• 批准号: 2411848
• 负责人: THERESE K KILLEEN
• 金额: $ 1.42万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-03-23 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/2411848
• 关键词: acupuncture /acupressure; alternative medicine; clinical research; cocaine; cues; drug abuse therapy; drug addiction; drug withdrawal; ear; human subject; human therapy evaluation; nursing intervention; placebos; questionnaires

This study will use a pretest posttest crossover design with subjects serving as their own controls to test the efficacy of auricular acupuncture interventions in diminishing psychological and physiological changes associated with cocaine craving in treatment seeking cocaine dependent patients. Cocaine craving is conceptualized as a multidimensional drive state with psychological and/or physiological correlates that often lead to drug consumption. Auricular acupuncture is an intervention consisting of insertion of needles into specific areas in the ear for the purpose of alleviating distressing symptoms associated with drug addiction and withdrawal. Ear point locations specifically targeted for drug withdrawal will represent the "real" acupuncture intervention. Ear point locations not targeted for any specific therapeutic benefit will represent the "sham" or placebo acupuncture. Thirty subjects will be randomized to receive either the real or sham acupuncture first. Twenty-four hours later each subject will receive the other acupuncture intervention. Subjects will be exposed to a cocaine cue before and after each intervention in order to simulate a craving. Cues are internal and/or external stimuli that serve as drug using reminders. A ten minute video showing individuals using cocaine will be utilized as the cue exposure. Psychological (Cocaine Craving Questionnaire-NOW) and physiological (electrodermal activity) changes associated with cocaine craving will be measured after the initial cue exposure but before the interventions, as well as after the interventions and a repeated cue exposure. Data will be analyzed using analysis of covariance (ANCOVA).

本研究将采用前后测交叉设计， 作为自己的对照，以测试耳穴的功效。 针灸干预减少心理和 治疗中与可卡因渴求相关的生理变化 寻找可卡因依赖者coconut渴望是概念化的 作为一种多维的驱动状态，具有心理和/或 生理上的关联往往导致吸毒。耳廓 针灸是一种干预，包括将针插入 在耳朵的特定区域，以减轻痛苦 与毒瘾和戒断相关的症状。耳穴 专门针对药物戒断的地点将代表 “真实的”针灸干预。耳穴位置不针对 任何特定的治疗益处将代表“假”或安慰剂 针灸30例受试者将随机接受 先用真实的针灸还是假针灸。24小时后，每个受试者 将接受另一种针灸干预。受试者将 在每次干预之前和之后暴露于可卡因线索， 假装渴望线索是内部和/或外部刺激， 作为吸毒的提醒。一段10分钟的视频展示了人们使用 可卡因将被用作线索暴露。心理学（心理学 渴望性食欲-NOW）和生理性（皮肤电活动） 与可卡因渴望相关的变化将在 最初的线索暴露，但在干预之前，以及之后， 干预和重复的线索暴露。将使用以下方法分析数据： 协方差分析（ANCOVA）。