OBSERVER PERFORMANCE STUDIES--CASE SELECTION ISSUES

观察者表现研究——案例选择问题

• 批准号: 2414399
• 负责人: DAVID GUR
• 金额: $ 5.64万
• 依托单位: ALLEGHENY UNIVERSITY OF HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-05-01 至 1998-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2414399
• 关键词: behavioral /social science research tag; case history; clinical research; diagnosis design /evaluation; diagnosis quality /standard; health care personnel performance; human data; imaging /visualization /scanning; method development; statistics /biometry

Many of the investigations that are now carried out during imaging systems' evaluations and comparisons include interpretation (reading) studies of normal and abnormal cases that are evaluated by receiver operating characteristics (ROC) or derivative thereof. Unfortunately, if one takes into account case selection representation and reader variability most studies would require a prohibitively large sample size to produce adequate statistical power for a statistically significant discrimination between reading modes in a manner which is both clinically relevant and generalizable. Approaches to case selection protocols for observer performance studies in this field have been largely arbitrary. We propose to investigate the possibility that the implementation of specific case selection protocols could allow one to focus on limited clinical questions which can be conclusively answered with an observer performance study requiring a much smaller sample size; hence, making such studies much more feasible and reasonable to perform. In addition, in conjunction with data on the proportion of such cases in the clinical environment (general ensemble of images), generalization of the results and or inference on the impact on clinical practices could be done.

现在在成像过程中进行的许多调查 系统的评估和比较包括解释（阅读） 由受试者评估的正常和异常病例研究 操作特性（ROC）或其衍生物。不幸的是如果 一个是考虑到案例选择表示和读者 变异性大多数研究需要过大的样本量 为了产生足够的统计功效， 以一种临床上 相关性和可推广性。 案例选择协议的方法 这一领域的观察员绩效研究在很大程度上是任意的。 我们建议调查实施 具体的病例选择协议可以使人们专注于有限的 可以由观察者最终回答的临床问题 性能研究需要更小的样本量;因此， 研究更加可行和合理。另外在 结合临床中此类病例比例的数据， 环境（图像的一般集合），结果的概括 和/或推断对临床实践的影响。