EXPERIMENTAL AND THEORETICAL STUDY OF DHFR KINETICS

我在本科维奇实验室选择了一个博士后职位，以便 应用我以前在理论生物物理和化学物理方面的训练 到目前感兴趣的生物系统。我选择DHFR是因为 丰富的实验信息可用，因为相关的过程 通过实验和实验相结合的方法对反应动力学进行了研究。 理论方法。本科维奇博士是酶类研究的领先者 反应，提供了对动力学机制的重要见解 用于DHFR、催化抗体、单加氧酶、聚合酶和其他 酵素。

I have selected a postdoctoral position in the Benkovic Lab in order to apply my previous training in theoretical biophysics and chemical physics to biological systems of current interest. I chose DHFR because of the wealth of experimental information available, and because processes related to the reaction dynamics are tractable by a combined experimental and theoretical approach. Dr. Benkovic is a leader in the study of enzymatic reactions, having provided significant insight on the kinetic mechanisms for DHFR, catalytic antibodies, monoxygenases, polymerases and other enzymes.