EXPERIMENTAL AND THEORETICAL STUDY OF DHFR KINETICS

DHFR 动力学的实验和理论研究

• 批准号: 2459265
• 负责人: WILLIAM R CANNON
• 金额: $ 1.5万
• 依托单位: PENNSYLVANIA STATE UNIVERSITY, THE
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-08-01 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/2459265
• 关键词: Escherichia coli; dihydrofolate reductase; enzyme activity; enzyme mechanism; radiotracer; site directed mutagenesis

I have selected a postdoctoral position in the Benkovic Lab in order to apply my previous training in theoretical biophysics and chemical physics to biological systems of current interest. I chose DHFR because of the wealth of experimental information available, and because processes related to the reaction dynamics are tractable by a combined experimental and theoretical approach. Dr. Benkovic is a leader in the study of enzymatic reactions, having provided significant insight on the kinetic mechanisms for DHFR, catalytic antibodies, monoxygenases, polymerases and other enzymes.

我选择了本科维奇实验室的博士后职位， 运用我以前在理论生物物理学和化学物理学方面的训练 当前感兴趣的生物系统。 我选择DHFR是因为 丰富的实验信息，因为过程相关 的反应动力学是易于处理的结合实验和 理论方法。 本科维奇博士是酶促反应研究的领导者 反应，提供了重要的洞察动力学机制 对于DHFR，催化抗体，单加氧酶，聚合酶和其他 内切酶