IMPROVED BIOARTIFICAL LIVER FUNCTION IN HEPATIC FAILURE
IMPROVED BIOARTIFICAL LIVER FUNCTION IN HEPATIC FAILURE
批准号:
2458788
负责人:
RORY P REMMEL
金额:
$18.55万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1992
资助国家:
美国
项目状态:
已结题
起止时间:
1992-09-30 至 2001-07-31
中文摘要
描述:(改编自申请人摘要)本申请
建议开发生物人工肝(BAL)作为桥接
用于肝移植或患者自发恢复的装置
急性肝功能衰竭 当前开发的BAL的问题是
肝细胞失去了重要的合成和生物转化
功能协调发展的 实验室的初步工作表明,细胞/细胞和
细胞/基质相互作用对于肝细胞分化是重要的,
功能 补助金的假设是,通过了解和
操纵参与细胞/基质和细胞/细胞的粘附受体
肝细胞分化和生物转化的相互作用,
改善,并因此改善BAL的功效。 具体目标
是:1. 为了证明大鼠和大鼠之间的粘附受体相互作用,
猪肝细胞和培养基质或其它肝细胞调节
生物转化功能; 2. P450的药物诱导是基质依赖性的
并将增强BAL的生物转化能力; 3. 到
证明由基质包埋肝细胞组成的优化BAL
用P450诱导剂的组合预处理的球状体将提供
在犬肝功能衰竭模型中的上级治疗功效。
英文摘要
DESCRIPTION: (Adapted from the applicant's abstract) This application
proposes to develop a bioartificial liver (BAL) to be used as a bridging
device to liver transplantation or for spontaneous recovery for patients
with acute liver failure. The problems with the currently developed BAL are
that the liver cells lose important synthetic and biotransformation
functions. Preliminary work from the laboratory suggests that cell/cell and
cell/matrix interactions are important for hepatocyte differentiation and
function. The hypothesis of the grant is that by understanding and
manipulating adhesion receptors involved in cell/matrix and cell/cell
interactions that hepatocyte differentiation and biotransformation can be
improved, and therefore improve the efficacy of a BAL. The Specific Aims
are: 1. To demonstrate that adhesion receptor interactions between rat or
porcine hepatocytes and the culture substratum or other liver cells regulate
biotransformation functions; 2. Drug induction of P450 is matrix dependent
and will enhance the biotransformation capacity of the BAL; 3. To
demonstrate that an optimized BAL consisting of matrix entrapped hepatocyte
spheroids pretreated with a combination of P450 inducers will provide
superior therapeutic efficacy in a canine liver failure model.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Meropenem Prodrugs for XDR-TB
-
批准号:8426082
-
项目类别:
-
资助金额:$22.44万
-
财政年份:2012
-
负责人:RORY P REMMEL
-
依托单位:
Meropenem Prodrugs for XDR-TB
-
批准号:8241437
-
项目类别:
-
资助金额:$17.85万
-
财政年份:2012
-
负责人:RORY P REMMEL
-
依托单位:
PROJECT 2: EFFECT OF AGING ON GLUCURONIDATION OF ANTIEPILEPTIC DRUGS
-
批准号:7605990
-
项目类别:
-
资助金额:$0.3万
-
财政年份:2006
-
负责人:RORY P REMMEL
-
依托单位:
EFFECT OF AGING ON GLUCURONIDATION OF ANTIEPILEPTIC DRUGS-LAMOTRIGINE (LAMICTAL)
-
批准号:7606089
-
项目类别:
-
资助金额:$1.76万
-
财政年份:2006
-
负责人:RORY P REMMEL
-
依托单位:
Effect of age on glucuronidation of antiepileptic drugs
-
批准号:7119179
-
项目类别:
-
资助金额:$33.45万
-
财政年份:2005
-
负责人:RORY P REMMEL
-
依托单位:
PROJECT 2: EFFECT OF AGING ON GLUCURONIDATION OF ANTIEPILEPTIC DRUGS
-
批准号:7206501
-
项目类别:
-
资助金额:$1.31万
-
财政年份:2005
-
负责人:RORY P REMMEL
-
依托单位:
PROJECT 2: EFFECT OF AGING ON GLUCURONIDATION OF ANTIEPILEPTIC DRUGS
-
批准号:7375909
-
项目类别:
-
资助金额:$1.76万
-
财政年份:2005
-
负责人:RORY P REMMEL
-
依托单位:
Effect of age on glucuronidation of antiepileptic drugs
-
批准号:6666465
-
项目类别:
-
资助金额:$29.76万
-
财政年份:2002
-
负责人:RORY P REMMEL
-
依托单位:
STUDIES ON THE N-GLUCURONIDATION OF ANTIEPILEPTIC DRUGS
-
批准号:3023456
-
项目类别:
-
资助金额:$3.52万
-
财政年份:1993
-
负责人:RORY P REMMEL
-
依托单位:
IMPROVED BIOARTIFICAL LIVER FUNCTION IN HEPATIC FAILURE
-
批准号:6177328
-
项目类别:
-
资助金额:$20.58万
-
财政年份:1992
-
负责人:RORY P REMMEL
-
依托单位:
IMPROVED BIOARTIFICAL LIVER FUNCTION IN HEPATIC FAILURE
-
批准号:2749482
-
项目类别:
-
资助金额:$19.2万
-
财政年份:1992
-
负责人:RORY P REMMEL
-
依托单位:
IMPROVED BIOARTIFICAL LIVER FUNCTION IN HEPATIC FAILURE
-
批准号:2905498
-
项目类别:
-
资助金额:$19.87万
-
财政年份:1992
-
负责人:RORY P REMMEL
-
依托单位:
CARBOVIR PRODRUGS--SYNTHESIS, METABOLISM, AND KINETICS
-
批准号:3142590
-
项目类别:
-
资助金额:$12.03万
-
财政年份:1989
-
负责人:RORY P REMMEL
-
依托单位:
CARBOVIR PRODRUGS--SYNTHESIS, METABOLISM, AND KINETICS
-
批准号:3142587
-
项目类别:
-
资助金额:$14.0万
-
财政年份:1989
-
负责人:RORY P REMMEL
-
依托单位:
CARBOVIR PRODRUGS--SYNTHESIS, METABOLISM, AND KINETICS
-
批准号:3142589
-
项目类别:
-
资助金额:$11.56万
-
财政年份:1989
-
负责人:RORY P REMMEL
-
依托单位:
Effect of age on glucuronidation of antiepileptic drugs
-
批准号:7281603
-
项目类别:
-
资助金额:$33.45万
-
财政年份:--
-
负责人:RORY P REMMEL
-
依托单位:
海外基金