EFFECT OF AGING ON GLUCURONIDATION OF ANTIEPILEPTIC DRUGS-LAMOTRIGINE (LAMICTAL)

衰老对抗癫痫药物拉莫三嗪（LAMICTAL）葡萄糖醛酸化的影响

• 批准号: 7606089
• 负责人: RORY P REMMEL
• 金额: $ 1.76万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7606089
• 关键词: Admission activity; Antiepileptic Agents; Computer Retrieval of Information on Scientific Projects Database; Dose; Drug Kinetics; Frequencies; Funding; Grant; Institution; Intravenous; Metabolic Pathway; Metabolism; Pharmaceutical Preparations; Research; Research Personnel; Resources; Source; United States National Institutes of Health; age effect; lamotrigine

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This project will examine the pharmacokinetics and metabolism of lamortiine after intravenous (IV) admission of lamotrigine. The results from this study will be used to assess the dosing frequency, alterations in metabolic pathways, changes in total drug concentration, and accumulation of active metabolites.

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