EFFECT OF AGING ON GLUCURONIDATION OF ANTIEPILEPTIC DRUGS-LAMOTRIGINE (LAMICTAL)

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 本项目将研究静脉注射拉莫三嗪后拉莫替丁的药代动力学和代谢。这项研究的结果将用于评估给药频率、代谢途径的变化、总药物浓度的变化以及活性代谢物的积累。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This project will examine the pharmacokinetics and metabolism of lamortiine after intravenous (IV) admission of lamotrigine. The results from this study will be used to assess the dosing frequency, alterations in metabolic pathways, changes in total drug concentration, and accumulation of active metabolites.