EFFECT OF AGING ON GLUCURONIDATION OF ANTIEPILEPTIC DRUGS-LAMOTRIGINE (LAMICTAL)

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This project will examine the pharmacokinetics and metabolism of lamortiine after intravenous (IV) admission of lamotrigine. The results from this study will be used to assess the dosing frequency, alterations in metabolic pathways, changes in total drug concentration, and accumulation of active metabolites.