PROJECT 2: EFFECT OF AGING ON GLUCURONIDATION OF ANTIEPILEPTIC DRUGS

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。65岁以上的人分解（代谢）药物的方式与年轻人不同。目前尚不清楚为什么会发生这种情况，也不知道老年人是如何分解这些药物的。这些差异可能表明，需要给老年人较低剂量的药物，以避免可能的毒性。我们感兴趣的是研究老年人在抗癫痫药物的代谢方面与年轻人有何不同，在这种情况下，是丙戊酸。这项研究可能表明，随着人们年龄的增长，丙戊酸的剂量应该降低。将对60名目前因癫痫或双相情感障碍而服用丙戊酸的男性和女性进行研究（18-50岁组20人，65-74岁组20人，70 - 75岁组20人）。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. People over age 65 years of age break down (metabolize) drugs differently than younger adults. It is not known why this happens nor how elderly people break down these drugs. These differences may show a need for lower doses of medications to be given to elderly individuals to avoid possible toxicity. We are interested in studying how the elderly differ from younger people in their metabolism of antiseizure medication, in this case, valproic acid. This research may indicate that doses of valproic acid should be lowered as people get older. Sixty males and females who are currently taking valproic acid for either epilepsy or bipolar disorder will be studied (20 in 18-50 yr group, 20 in 65-74 yr group and 20 in >75 yr group).