PROJECT 2: EFFECT OF AGING ON GLUCURONIDATION OF ANTIEPILEPTIC DRUGS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 65岁以上的人分解(代谢)药物的方式与年轻人不同。目前还不知道为什么会发生这种情况，也不知道老年人如何分解这些药物。这些差异可能表明需要给老年人服用较低剂量的药物，以避免可能的毒性。我们有兴趣研究老年人在抗癫痫药物代谢方面与年轻人的不同之处，在这种情况下，丙戊酸。这项研究可能表明，随着年龄的增长，丙戊酸的剂量应该降低。目前正在服用丙戊酸治疗癫痫或双相情感障碍的60名男性和女性将被研究(18-50岁组20人，65-74岁组20人，75岁组20人)。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. People over age 65 years of age break down (metabolize) drugs differently than younger adults. It is not known why this happens nor how elderly people break down these drugs. These differences may show a need for lower doses of medications to be given to elderly individuals to avoid possible toxicity. We are interested in studying how the elderly differ from younger people in their metabolism of antiseizure medication, in this case, valproic acid. This research may indicate that doses of valproic acid should be lowered as people get older. Sixty males and females who are currently taking valproic acid for either epilepsy or bipolar disorder will be studied (20 in 18-50 yr group, 20 in 65-74 yr group and 20 in >75 yr group).