PROJECT 2: EFFECT OF AGING ON GLUCURONIDATION OF ANTIEPILEPTIC DRUGS

项目2：衰老对抗癫痫药物葡萄糖醛酸化的影响

• 批准号: 7605990
• 负责人: RORY P REMMEL
• 金额: $ 0.3万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7605990
• 关键词: Age-Years; Antiepileptic Agents; Bipolar Disorder; Computer Retrieval of Information on Scientific Projects Database; Dose; Elderly; Epilepsy; Female; Funding; Grant; Individual; Institution; Metabolism; Pharmaceutical Preparations; Research; Research Personnel; Resources; Source; Toxic effect; United States National Institutes of Health; Valproic Acid; age effect; interest; male; young adult

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. People over age 65 years of age break down (metabolize) drugs differently than younger adults. It is not known why this happens nor how elderly people break down these drugs. These differences may show a need for lower doses of medications to be given to elderly individuals to avoid possible toxicity. We are interested in studying how the elderly differ from younger people in their metabolism of antiseizure medication, in this case, valproic acid. This research may indicate that doses of valproic acid should be lowered as people get older. Sixty males and females who are currently taking valproic acid for either epilepsy or bipolar disorder will be studied (20 in 18-50 yr group, 20 in 65-74 yr group and 20 in >75 yr group).

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 65岁以上的人分解（代谢）药物的方式与年轻人不同。 目前尚不清楚为什么会发生这种情况，也不知道老年人如何分解这些药物。这些差异可能表明，老年人需要较低剂量的药物，以避免可能的毒性。我们感兴趣的是研究老年人与年轻人在抗癫痫药物代谢方面的差异，在这种情况下，丙戊酸。这项研究可能表明，随着人们年龄的增长，丙戊酸的剂量应该降低。将研究60名目前正在服用丙戊酸治疗癫痫或双相情感障碍的男性和女性（18-50岁组20名，65-74岁组20名，>75岁组20名）。