ULTRASONIC ANALYSIS OF SOFT TISSUE STRUCTURE

软组织结构的超声分析

• 批准号: 2391433
• 负责人: Michael F Insana
• 金额: $ 15.54万
• 依托单位: UNIVERSITY OF KANSAS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-02-01 至 1999-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2391433
• 关键词: biomedical equipment development; blood flow measurement; clinical biomedical equipment; computer program /software; computer system design /evaluation; computer system hardware; cyclosporines; diagnosis design /evaluation; diagnosis quality /standard; dogs; endothelin; histology; image processing; immunosuppressive; kidney circulation; kidney disorder diagnosis; kidney imaging /visualization; mathematical model; microcirculation; noninvasive diagnosis; phantom model; statistics /biometry; ultrasonography; vasoconstriction

We propose a plan to develop instrumentation and adaptive estimation techniques for implementing quantitative ultrasound methods to study renal physiology and disease mechanisms. Our first aim is to assemble an electronic system for estimating acoustic properties and forming parametric images at high speeds. The goal is to provide the means for investigating dynamic physiological processes and eventually to study human subjects. Our second aim is to investigate the sensitivity of these measurements and explore a potential solution to the important clinical problem of managing organ transplant rejection. Our third aim is to use Bayesian estimation methods to include the information acquired over the past three years on normal tissues into the estimation process and hereby improve measurement sensitivity. Our fourth aim is to construct test media and a CD phantom or use throughout the project but particularly in Aim 1; to measure important statistical properties of the data for use in Aim 3; to analyze measurement uncertainty and better understand the limitations of this approach to quantitative ultrasound. Having established feasibility of the techniques in the previous project period we now turn on developing and refining our hardware and software tools for investigating live tissues.

我们提出了一个计划，发展仪器和自适应估计 实施定量超声方法研究肾脏的技术 生理学和疾病机制。 我们的第一个目标是组装一个电子系统， 特性和高速形成参数图像。 目标是 提供研究动态生理过程的手段， 最终用于研究人体。我们的第二个目标是调查 这些测量的敏感性，并探讨一个潜在的解决方案， 器官移植排斥反应处理的重要临床问题。我们 第三个目标是使用贝叶斯估计方法来包含信息 在过去三年中获得的正常组织进入估计 工艺，从而提高测量灵敏度。我们的第四个目标是 构建测试介质和CD体模或在整个项目中使用，但 特别是在目标1中;测量 目标3中使用的数据;分析测量不确定度， 了解这种定量超声方法的局限性。 在确定了上一个项目中技术的可行性后， 我们现在开始开发和完善我们的硬件和软件 研究活体组织的工具。