BIOtAK Ltd - Proof of Concept of PEROXItAK and STEAMtAK

BIOtAK Ltd - PEROXItAK 和 STEAMtAK 的概念证明

• 批准号: 710309
• 金额: $ 3.66万
• 依托单位: BIOTAK LIMITED
• 依托单位国家: 英国
• 项目类别: GRD Proof of Concept
• 财政年份: 2013
• 资助国家: 英国
• 起止时间: 2013 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=710309
• 关键词: BIOtAK; Ltd; Proof; Concept; PEROXItAK

In hospitals, surgical instruments are processed for reuse in the Sterile Services Dept (SSD).After being washed and disinfected, the instruments are sterilised in a hydrogen peroxideplasma or steam device. The ability to check that the sterilisation process is functioningproperly ensures that pathogen levels have been reduced to a sufficient level so as not totransmit disease to the following patient.BIOtAK is developing two devices, PEROXItAK and STEAMtAK, to monitor sterilisationprocesses which use hydrogen peroxide and steam respectively as the sterilant. The keyobjective of this project is to perform specialist testing of these products to obtain proof ofconcept. These products use innovative enzyme based technology that provides an objective,unambiguous, rapid and quantifiable result which is a first in this sector. Existing tests canachieve at best only one or two of these capabilities at a time. PEROXItAK and STEAMtAKwould make up 2 distinct work packages.The aims of these projects are to use a test rig to evaluate the potential of PEROXItAK tomonitor hydrogen peroxide based sterilisation processes. In addition this package will involvethe formulation of test devices to ensure they are suitable for use for this application. ForSTEAMtAK the aim is to evaluate possible enzyme formulations that can monitor the steamsterilisation process. Testing will determine if there is remaining enzyme activity at 140°C dryheat after 30 minutes as required by the chemical indicator standards, and also assess in thepresence of saturated steam.The Health Protection Agency (HPA) has been carrying out research on enzymes calledthermostable Kinases which are very robust enzymes. Thermostable Adenylate Kinase (tAK)has been developed by BIOtAK as a wash process indicator in hospitals for surgicalinstruments. Now BIOtAK wishes to assess the application of this enzyme technology tomonitor sterilisation processes.

在医院，手术器械在消毒服务部（SSD）进行再利用处理。清洗和消毒后，器械在过氧化氢等离子体或蒸汽装置中灭菌。检查灭菌过程是否正常运行的能力确保病原体水平已降低到足够的水平，从而不会将疾病传播给下一个患者。BIOtAK正在开发两种设备，PEROXItAK和STEAMtAK，以监控分别使用过氧化氢和蒸汽作为灭菌剂的灭菌过程。该项目的主要目标是对这些产品进行专业测试，以获得概念验证。这些产品采用创新的酶技术，提供了一个客观，明确，快速和可量化的结果，这是第一次在这个部门。现有的测试一次最多只能实现其中的一个或两个功能。PEROXItAK和STEAMtAK将组成两个不同的工作包。这些项目的目的是使用测试装置来评估PEROXItAK监控基于过氧化氢的灭菌过程的潜力。此外，该包装将涉及测试设备的配方，以确保它们适用于此应用。对于STEAMtAK，目的是评估可以监测蒸汽灭菌过程的可能的酶制剂。测试将确定是否有剩余的酶活性在140°C干热后30分钟所需的化学指标标准，并在存在饱和蒸汽的情况下进行评估。健康保护局（HPA）一直在进行研究的酶称为热稳定激酶，这是非常强大的酶。热稳定腺苷酸激酶（tAK）是由BIOtAK开发的一种用于医院医疗器械清洗过程的指示剂。现在BIOtAK希望评估这种酶技术在监控灭菌过程中的应用。