Automating a platform for rapid clinical microbiology

快速临床微生物学自动化平台

• 批准号: 710319
• 金额: $ 10.86万
• 依托单位: MOMENTUM BIOSCIENCE LIMITED
• 依托单位国家: 英国
• 项目类别: GRD Proof of Concept
• 财政年份: 2013
• 资助国家: 英国
• 起止时间: 2013 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=710319
• 关键词: Automating; platform; rapid; clinical; microbiology

The Company has developed a test allowing the hospital microbiology laboratory to rapidlydetect bacterial and fungal infections in blood. Current methods usually take 1-3 days to tell ifa blood specimen is positive and 5 days to report if it is negative. The new test provides bothpositive and negative results in 24 hours which helps to save hospital costs and unnecessaryantibiotic use and will assist in difficult diagnoses. However the test takes 3 hours for atrained scientist to perform. This manual requirement makes it harder for a busy lab to fit thenew test into its daily workflowThe SMART project is intended to show proof of concept for an automated version of the test.Running the test on an instrument requires development of new methods for separating microorganismsfrom blood contaminants and this is a key risk factor in the project. It is intendedthat the final automated method will reduce the amount of hands on time required by lab staffto a matter of minutes and allow higher numbers of tests to be run per day with improvedaccuracy. Hospital microbiologists have said that making the test easier for the lab to run willmake adoption much more likely and this is expected to boost sales significantly in the UKand worldwide. If the SMART proof of concept is successful the Company intends tocomplete development and launch the automated detection product as well as apply thisautomation to future products.

该公司开发了一种测试，允许医院微生物实验室快速检测血液中的细菌和真菌感染。目前的方法通常需要1-3天来告诉ifa血液标本是阳性和5天报告，如果是阴性。新的测试在24小时内提供阳性和阴性结果，这有助于节省医院费用和不必要的抗生素使用，并有助于困难的诊断。然而，测试需要3个小时的专业科学家来执行。这种手动要求使得忙碌的实验室更难将新的测试融入日常工作流程。SMART项目旨在展示自动化测试版本的概念证明。在仪器上运行测试需要开发新的方法来分离微生物和血液污染物，这是项目中的一个关键风险因素。最终的自动化方法将把实验室工作人员所需的动手时间减少到几分钟，并允许每天运行更多的测试，同时提高准确性。医院的微生物学家说，让实验室更容易运行测试将使采用更有可能，这有望大大提高在英国和世界范围内的销售。如果SMART概念验证成功，该公司打算完成开发并推出自动检测产品，以及将此自动化应用于未来的产品.