ASTROGLIOSIS AND EPILEPTOGENESIS

星形胶质细胞增多症和癫痫发生

• 批准号: 2445687
• 负责人: Guy M McKhann
• 金额: $ 3.53万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-07-01 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/2445687
• 关键词: astrocytes; brain electrical activity; epilepsy; extracellular; gliosis; hippocampus; histopathology; human tissue; ion transport; kainate; laboratory rat; potassium

Although glial scarring has long been associated with focal epilepsy, studies to date have failed to establish a pathophysiologic linkage. There is increasing evidence however that central nervous system astrocytes play an essential role in regulating extracellular ion homeostasis and extracellular space (ECS) size in response to neuronal activity. Preliminary results have shown that altering different glial mechanisms that regulate the extracellular environment can either result in an increase of decrease of neuronal synchronization. In normal hippocampal slices, blocking potassium uptake into glia results in epileptiform activity. In contrast, preventing ECS shrinkage antagonizes epileptiform activity in both in vitro and acute animal models of epilepsy. We propose to study astrocytic regulation of the extracellular environment in the kainate rat model of chronic temporal lobe epilepsy and in human specimens from temporal lobed epilepsy resections. We will test the hypothesis that there is altered regulation of potassium and/or ECS size by the astrocyte syncytium in gliotic hippocampus from kainate treated rats and human surgical specimens from temporal lobe epilepsy resections.

虽然神经胶质瘢痕一直与局灶性癫痫有关，

项目成果

Functional specialization and topographic segregation of hippocampal astrocytes.

海马星形胶质细胞的功能特化和拓扑分离。

• DOI: 10.1523/jneurosci.18-12-04425.1998
• 发表时间: 1998
• 期刊: The Journal of neuroscience : the official journal of the Society for Neuroscience
• 作者: D'Ambrosio,R;Wenzel,J;Schwartzkroin,PA;McKhann2nd,GM;Janigro,D
• 通讯作者: Janigro,D