SLEEP DEPRIVATION EFFECTS ON VIGILANCE AND REGIONAL BRAIN ELECTRICAL ACTIVITY

研究表明，睡眠不足对两人都有调节情绪的作用 正常受试者和重度抑郁障碍患者，但 这些影响的机制尚不清楚。睡眠不足也会导致 昏昏欲睡，这会对表现产生重大影响， 尤其是在低刺激的情况下。警戒级别的测量 可以帮助预测性能下降，但目前可用 在性能设置中，措施要么很难管理 或者不是很可靠。本研究的目的是：(1) 描述睡眠剥夺对正常人群情绪的影响 受试者，以及(2)评估惊吓反应的有效性 测量警戒级别。受试者将接受电生理检查 区域脑功能和情绪调节惊吓的测量 一晚正常睡眠和一晚合计睡眠后的反应 睡眠不足。

Sleep deprivation has been shown to have mood-modulating effects in both normal subjects and patients with major depressive disorder, but the mechanism for these effects are unknown. Sleep deprivation also leads to sleepiness, which can impact significantly on performance, particularly in low-stimulus situations. Measurement of vigilance level could help to predict performance lapses, but currently available measures are either difficult to administer in performance settings or not highly reliable. The purposes of this study are to (1) characterize the effects of sleep deprivation on mood in normal subjects, and (2) assess the effectiveness of the startle response in measuring vigilance level. Subjects will undergo electrophysiological measures of regional brain function and emotion-modulated startle responses following a night of normal sleep and after one night of total sleep deprivation.