Molecular determinants of inflammatory caspase activity upon inflammasomes

炎症小体炎症半胱天冬酶活性的分子决定因素

• 批准号: DP190102285
• 负责人: Prof Kate Schroder
• 金额: $ 34.76万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-01-10 至 2022-01-09
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP190102285
• 关键词: Molecular; determinants; inflammatory; caspase; activity

Most processes fundamental to life rely on the timely, and regulated, execution of cellular functions. The innate immune system, in which both timing and regulation is paramount, rapidly detects invading microbes and induces a measured and timely antimicrobial response to clear infection. This project aims to address a key knowledge gap by characterising a mechanism for timely and controlled immune system activation and immune cell death via the non-canonical inflammasome. We do not currently understand how some immune pathways are turned on or off. This project will yield fundamental insight into mechanisms of mammalian inflammasome, inflammation and anti-microbial responses.

大多数生命的基本过程依赖于细胞功能的及时和受控制的执行。在先天免疫系统中，时机和调节都是至关重要的，它可以快速检测入侵的微生物，并诱导出有节制和及时的抗菌素反应，以清除感染。该项目旨在通过描述一种通过非典型炎症小体及时和受控的免疫系统激活和免疫细胞死亡的机制来解决一个关键的知识缺口。我们目前还不知道某些免疫通路是如何开启或关闭的。这个项目将对哺乳动物炎症小体、炎症和抗微生物反应的机制产生基本的洞察。