Pyroptotic macrophages posthumously sculpt immune responses

焦亡巨噬细胞在死后塑造免疫反应

• 批准号: DP230100300
• 负责人: Prof Kate Schroder
• 金额: $ 40.2万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2023
• 资助国家: 澳大利亚
• 起止时间: 2023-01-19 至 2026-01-18
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP230100300
• 关键词: Pyroptotic; macrophages; posthumously; sculpt; immune

The life of an organism relies on the timely birth and death of its cells. Importantly, it is crucial for cells to die not only at the right time, but also in an appropriate manner. This proposal investigates a cell death pathway that triggers potent immune responses. This proposal seeks to reveal precisely how cell death sculpts immune responses. Expected outcomes include new insights into how immune cells die, and how they instruct immune responses from beyond the grave. Project benefits include a fundamental understanding of how cell death signalling sculpts tissue immune responses, and knowledge of how to manipulate cell death responses for future basic research and commercial applications beyond this project.

生物体的生命依赖于其细胞适时的出生和死亡。重要的是，细胞不仅要在正确的时间死亡，而且要以适当的方式死亡。该提案研究了引发有效免疫反应的细胞死亡途径。这项提议试图精确地揭示细胞死亡如何塑造免疫反应。预期的成果包括对免疫细胞如何死亡以及它们如何从坟墓中指导免疫反应的新见解。项目的好处包括对细胞死亡信号如何塑造组织免疫反应的基本理解，以及如何操纵细胞死亡反应以用于本项目以外的未来基础研究和商业应用的知识。