A molecular timer for inflammation and cell death

炎症和细胞死亡的分子计时器

• 批准号: DP160102702
• 负责人: Prof Kate Schroder
• 金额: $ 34.92万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP160102702
• 关键词: molecular; timer; inflammation; cell; death

This project aims to improve our understanding of the timely function of the immune system. Most processes fundamental to life rely on the timely execution of cellular functions. One biological system in which timing is paramount is the immune system. Organismal health relies upon this front-line defence system for rapidly detecting invading microbes and inducing an appropriate, and timely, antimicrobial response to clear infection. We do not currently understand how immune responses are temporally coordinated. This proposal aims to address this key knowledge gap by characterising a novel molecular timer that dictates the co-ordinated timing of immune responses and immune cell death. These studies may yield fundamental insight into mammalian anti-microbial mechanisms.

该项目旨在提高我们对免疫系统及时功能的理解。生命的大多数基本过程都依赖于细胞功能的及时执行。免疫系统是一个生物系统，其中时间是至关重要的。生物体健康依赖于这种前线防御系统，以快速检测入侵的微生物，并诱导适当，及时的抗菌反应，以清除感染。我们目前还不了解免疫反应是如何在时间上协调的。该提案旨在通过表征一种新的分子计时器来解决这一关键的知识缺口，该计时器决定了免疫反应和免疫细胞死亡的协调时间。这些研究可能对哺乳动物抗微生物机制产生根本性的洞察。