Inflammasomes: molecular drivers of anti-microbial defence

炎症小体：抗微生物防御的分子驱动因素

• 批准号: FT130100361
• 负责人: Prof Kate Schroder
• 金额: $ 52.71万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: ARC Future Fellowships
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FT130100361
• 关键词: Inflammasomes; molecular; drivers; anti; microbial

The innate immune system is the body’s first line of defence against infection, but also drives unhealthy inflammation. Families of innate immune receptors, such as nucleotide-binding oligomerisation domain (NOD-like Receptors), were recently discovered to control both anti-microbial defence and unhealthy inflammation. This project will characterise the basic biology of NOD-like Receptors at the molecular, cellular and organismal levels, and will thereby lead to a greater understanding of the fundamental biological pathways controlling inflammation and defence against infection. This may ultimately lead to commercial opportunities for treating infection and chronic inflammation.

先天免疫系统是人体抵御感染的第一道防线，但也会引发不健康的炎症。先天免疫受体家族，如核苷酸结合寡聚化结构域（NOD样受体），最近被发现控制抗微生物防御和不健康的炎症。该项目将在分子，细胞和生物体水平上研究NOD样受体的基本生物学，从而更好地了解控制炎症和防御感染的基本生物学途径。这可能最终导致治疗感染和慢性炎症的商业机会。