AGE RELATED MACULOPATHY--DRUSEN BIOGENESIS

年龄相关性黄斑病变--玻璃疣的生物发生

• 批准号: 2459185
• 负责人: DON H ANDERSON
• 金额: $ 19.28万
• 依托单位: UNIVERSITY OF CALIFORNIA SANTA BARBARA
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-08-01 至 1999-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2459185
• 关键词: Primates; aging; binding proteins; blood proteins; electron microscopy; fluorescence microscopy; human tissue; immunocytochemistry; laboratory mouse; macular degeneration; macular drusen; pathologic process; polymerase chain reaction; protein biosynthesis; retinal pigment epithelium; vision disorders

DESCRIPTION (Adapted from applicant's abstract): AMD is characterized by the progressive loss of vision in the central visual field attributable to atrophic, exudative and/or hemorrhagic changes in the macula. No pharmacologic treatment has been shown to be effective in preventing, arresting, or reversing loss of vision associated with AMD. The proposed research has focused primarily on drusen, which are accumulations of extracellular material that develop between the retinal pigment epithelium (RPE) and its blood supply, the choriocapillaris. Relatively little is known about the origin or the composition of drusen, even though drusen deposits are considered widely as a significant risk factor for the development of both atrophic and exudative AMD. Preliminary studies of drusen composition have led to the identification of specific drusen-associated molecules (DRAMs), many of which are circulating plasma proteins and known participants in the processes of fibrinolysis, thrombosis, inflammation, and/or the immune response. In this proposal, the emphasis is on drusen biogenesis, the identification of the ligands for DRAMs in the RPE-choroid in the transcellular pathways involved in DRAM deposition. The experimental cell line in this as well as the two companion proposals are designed to clarify the relationship between ocular drusen, related choroidal abnormalities, and the subsequent development of atrophic AMD. In so doing, the applicants hope to establish a conceptual framework for pursuing additional basic and clinical research into the causes and prevention of AMD.

描述(改编自申请人的摘要)：AMD的特征 由中央视野进行性视力丧失所致 可归因于脑部的萎缩、渗出和/或出血性改变 黑斑。没有任何药物治疗被证明是有效的 预防、阻止或扭转与老年性黄斑变性相关的视力丧失。 拟议的研究主要集中在干酪，它们是 在视网膜之间形成的细胞外物质的堆积 色素上皮(RPE)及其血液供应，脉络膜毛细血管。 人们对它的起源或成分知之甚少。 绿泥石，尽管绿泥石矿床被广泛认为是一种 萎缩性和慢性萎缩性心脏病发生的重要危险因素 渗出性AMD。对软骨膜成分的初步研究导致了 鉴定特定的干酪蛋白相关分子(DRAM)，许多 其中包括循环中的血浆蛋白和已知的 纤溶、血栓、炎症和/或免疫过程 回应。在这项提案中，重点是干酪生物发生，即 视网膜色素上皮-脉络膜中DRAMs配体的鉴定 参与DRAM沉积的跨细胞通路。实验性的 在此设计了细胞系以及两个配套的方案 阐明眼部玻璃体与脉络膜的关系 异常，以及随后萎缩性AMD的发展。在苏中 这样做，申请者希望建立一个概念性的框架 正在进行更多的基础和临床研究，以了解病因和 AMD的预防。