NEURAL CONTROL MULTICHANNEL IMPLANTABLE SYSTEM

神经控制多通道植入系统

• 批准号: 2332968
• 负责人: Paul Hunter Peckham
• 金额: $ 38.79万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-05-01 至 1999-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2332968
• 关键词: bioengineering /biomedical engineering; biological signal transduction; biomedical equipment development; biosensor device; clinical research; dogs; electrophysiology; human subject; human therapy evaluation; implant; muscle function; nervous system prosthesis; neuromuscular stimulator; neuroregulation; rehabilitation; spinal cord injury; telemetry

The aim of this project is to implement and evaluate an advanced neuroprosthetic system for restoration of hand-arm function in human subjects who have sustained cervical level spinal cord injury. The neuroprosthesis will provide the person with C5 tetraplegia with control of grasp and release and elbow extension by electrical stimulation of the paralyzed muscles. These functions will enable the user to regain the versatile manipulative functions which will increase their ability to perform activities of daily living independently. Both the sensors which provide the control functions and the stimulation that activates the muscles will be implanted surgically. Thus, the user will be free from issues of sensor mounting and maintenance of cabling and connections to the leads and electrodes on the extremities. The neuroprosthesis to be implemented consists of an external control unit, a multichannel implanted stimulator-telemeter, implanted sensors which transduce joint angle, and electrodes which sense muscle activity (a myoelectric signal). This project will result in (1) completed development of all components of the neuroprosthetic system, (2) evaluation of the system in bench and in vivo testing, and (3) evaluation of its efficacy in five individuals. Outcome evaluations will measure the function of individual components of the neuroprosthesis and the performance of users in grasp-release tests and activities of daily living. These tests will allow statistical comparisons of the user's abilities before surgery with those achieved after surgery, both with the neuroprosthesis turned on and turned off. The results of this project will demonstrate the feasibility of a totally implanted neuroprosthesis and the significant improvements in hand function achieved through its use. The long term objectives of this research are to provide innovative techniques for restoration of functional movement in persons with central nervous system disorders. This research will develop the fundamental modules of neuroprosthetic systems for restoration of control of movement and sensation and perform clinical research to demonstrate their feasibility. The proposed system also has application in the efforts to provide standing and walking in thoracic level spinal cord injury, stroke, and head injury. These types of applications have been considered in defining the proposed system, so that it will be versatile across different clinical applications.

该项目的目的是实施和评估一个先进的 用于恢复人类手臂功能的神经假体系统 受试者患有持续的颈段脊髓损伤。 的 神经假体将为C5四肢瘫痪的人提供控制 的抓和释放和肘部伸展的电刺激， 肌肉麻痹这些功能将使用户能够重新获得 多功能的操作功能，这将增加他们的能力， 独立进行日常生活活动。这两个传感器， 提供控制功能和激活 肌肉将通过手术植入。因此，用户将免于 传感器的安装和电缆和连接的维护问题， 四肢上的导线和电极神经假体 实现包括一个外部控制单元，多通道 植入式刺激遥测仪，植入式传感器， 角，以及感知肌肉活动（肌电信号）的电极。 该项目将导致（1）完成所有组件的开发 神经假体系统的评价，（2）系统在台架上的评价， 体内测试，和（3）在五个个体中评价其功效。 成果评价将衡量各个组成部分的功能 和使用者在抓握-释放中的表现 测试和日常生活活动。这些测试将允许统计 用户术前能力与术后能力的比较 手术后，神经假体打开和关闭。 该项目的结果将证明一个完全可行的 植入的神经假体和手的显着改善 通过使用实现的功能。 这项研究的长期目标是提供创新的 中枢神经系统疾病患者功能性运动的恢复技术 神经系统疾病这项研究将发展基本的 用于恢复运动控制的神经修复系统模块 并进行临床研究，以证明他们的 可行性 所提出的系统还可以应用于提供 胸段脊髓损伤、中风和 头部受伤。这些类型的应用程序在定义 建议的系统，以便它将是通用的，在不同的 临床应用。