TRAJECTORY SPECIFICATION IN TARGETED LIMB MOVEMENT

描述：(申请者摘要)建议的实验审查 受试者如何学习控制他们的手的动作 个人周边空间。我们通过分析轨迹来解决这些问题 以及针对目标的运动中的肌肉激活模式 呈现在虚拟工作空间中。这些实验是建立在 在本次资助中获得的心理物理结果。这些都有 演示了手部运动的规划是在一个 以手为中心的矢量空间和方向精度 需要有关初始手部位置的外部信息。这个 矢量化手绘路径规划向运动程序的转换 在关节处产生必要的扭矩和旋转需要 学习肢体生物力学特性的内部模型。我们现在寻求 识别感觉信息在运动学习中的作用，使用新的 改变视觉运动变换和肢体动力学的范例 有选择地。在本研究的过程中，我们将研究 利用听觉信号提供关节信息的可行性 和手部动作。我们打算回答四组问题：(1)如何 关于运动误差的信息是否会自适应地改变空间 受试者用来计划运动范围和方向的陈述？ (2)表现出哪些运动特征或肢体特征 在体内由神经系统控制惯性相互作用？(3) 什么类型的感官信息对神经系统最有用 在更新其惯性性质的内部表示时， 肢体？(4)在动作执行、学习或 LIB惯性模型的生成负责 小脑病变患者的动作不准确？至 回答了这些问题，我们研究了对改变的显示的适应 肢体运动，以及肢体生物力学特性的改变 在三组受试者中进行检查：正常对照组，缺乏的患者 本体感觉(由于大纤维感觉神经病)，患者 有局限性的小脑损伤。听觉替代的使用 本体感觉改善去传入患者的肢体控制 将会被探索。

DESCRIPTION: (Applicant's Abstract) The proposed experiments examine how subjects learn to control the movements of their hand in peripersonal space. We address these questions by analyzing trajectories and muscle activation patterns during movements aimed to targets presented in a virtual workspace. The experiments build on psychophysical results obtained in the current grant. These have demonstrated that the planning of hand movements is carried out in a vectorial space centered at the hand and that directional accuracy requires extrinsic information about initial hand position. The transformation of a vectorial hand-path plan into a motor program producing the necessary torques and rotations at joints requires a learned internal model of limb biomechanical properties. We now seek to identify the roles of sensory information in motor learning, using new paradigms for altering visumotor transformation and limb dynamics selectively. In the course of this study we will examine the feasibility of using auditory signals to provide information about joint and hand motions. We aim to answer four sets of questions: (1) How does information about movement errors adaptively alter the spatial representations used by subjects to plan movements extent and direction? (2) What characteristics of movements or limb properties are represented internally by the nervous system, to control inertial interaction? (3) What types of sensory information are most useful to the nervous system in updating its internal representations of the inertial properties of the limb? (4) What disturbances in movement execution, learning or the generation of inertial models of the lib are responsible for the inaccuracy of movements made by patients with cerebellar lesions? To answered there questions we examine the adaptation to altered displays of limb motions, and to alteration sin limb biomechanical properties are examined in three groups of subjects: normal controls, patients lacking proprioception (because of large-fiber sensory neuropathy), patients with localized cerebellar lesions. the use of auditory substitution of proprioceptive sensation to improve limb control in deafferented patients will be explored.