IBEX Dynamic X-ray imaging of reduced iodine contrast agents in angiography procedures

IBEX创新公司在之前的原型开发项目中成功展示了其多吸收板(MAP)X射线探测器技术的材料分类能力。使用集成到标准医用平板探测器(FPD)中的MAP技术来识别医学图像中的物质的能力具有显著的好处，包括在标准的数字放射成像(DR)设备上测量骨密度(BMD)的能力。血管成像系统使用不透射线的造影剂(通常是碘溶液)的X射线吸收对比度来显示体内的血管和器官，并用于辅助诊断和治疗心脏疾病(冠脉血管成像)或大脑疾病(神经血管血管成像)。众所周知，在大约2%的血管造影术过程中，基于碘的造影剂通过对比剂诱导的肾病(CIN)损害肾功能，在高危患者中增加到20-30%。该项目旨在证明IBEX材料分类方法可以根据材料类型而不是其X射线阻挡特性来识别造影剂。这提供了成像低得多的碘浓度而不损失对比度的可能性，或者使用新型无害造影剂的可能性，这些造影剂可以根据其与身体结构的材料差异来区分。该项目还将展示IBEX材料分类技术可以实时生成运动对比剂的图像。最后，该项目将寻求展示在动态图像中抑制骨骼和组织作为数字减影血管造影(DSA)方法的替代方法。

IBEX Innovations has successfully demonstrated, in a previous Development of Prototype project, the materials classification capability of its Multi-Absorption Plate (MAP) X-ray detector technology. The ability to identify materials in a medical image using the MAP technology integrated to a standard medical flat panel detector (FPD) offers significant benefits, including the ability to measure bone mineral density (BMD) on standard Digital Radiography (DR) equipment.Angiography systems use X-ray absorption contrast of a radio-opaque contrast agent, usually an iodine solution, to visualise blood vessels and organs in the body and are used to assist in diagnosis and treatment of heart conditions (Coronary Angiography) or brain conditions (Neuro-vascular Angiography).Iodine-based contrast agents are known to impair renal function through Contrast Induced Nephropathy (CIN) in around 2% of angiography procedures, increasing to 20-30% in high risk patients. This project seeks to demonstrate that the IBEX materials classification methods can identify contrast agents by their material type rather than their X-ray blockingcharacteristics. This offers the potential to image much lower concentrations of iodine with no loss in contrast, or to use new types of non-harmful contrast media that can be distinguished by virtue of their material differences from the structures of the body. The project will also demonstrate that the IBEX materials classification technology can generate images of moving contrast agent in in real time. Finally, the project will seek to demonstrate suppression of bone and tissue in the dynamic image as an alternative approach to digital subtraction angiography (DSA) methods.