IBEX Dynamic X-ray imaging of reduced iodine contrast agents in angiography procedures

血管造影过程中减少碘造影剂的 IBEX 动态 X 射线成像

• 批准号: 710806
• 金额: $ 12.54万
• 依托单位: IBEX INNOVATIONS LTD
• 依托单位国家: 英国
• 项目类别: GRD Proof of Concept
• 财政年份: 2016
• 资助国家: 英国
• 起止时间: 2016 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=710806
• 关键词: IBEX; Dynamic; ray; imaging; reduced

IBEX Innovations has successfully demonstrated, in a previous Development of Prototype project, the materials classification capability of its Multi-Absorption Plate (MAP) X-ray detector technology. The ability to identify materials in a medical image using the MAP technology integrated to a standard medical flat panel detector (FPD) offers significant benefits, including the ability to measure bone mineral density (BMD) on standard Digital Radiography (DR) equipment.Angiography systems use X-ray absorption contrast of a radio-opaque contrast agent, usually an iodine solution, to visualise blood vessels and organs in the body and are used to assist in diagnosis and treatment of heart conditions (Coronary Angiography) or brain conditions (Neuro-vascular Angiography).Iodine-based contrast agents are known to impair renal function through Contrast Induced Nephropathy (CIN) in around 2% of angiography procedures, increasing to 20-30% in high risk patients. This project seeks to demonstrate that the IBEX materials classification methods can identify contrast agents by their material type rather than their X-ray blockingcharacteristics. This offers the potential to image much lower concentrations of iodine with no loss in contrast, or to use new types of non-harmful contrast media that can be distinguished by virtue of their material differences from the structures of the body. The project will also demonstrate that the IBEX materials classification technology can generate images of moving contrast agent in in real time. Finally, the project will seek to demonstrate suppression of bone and tissue in the dynamic image as an alternative approach to digital subtraction angiography (DSA) methods.

IBEX Innovations在之前的原型开发项目中成功展示了其多吸收板（MAP）X射线探测器技术的材料分类能力。使用集成到标准医用平板探测器（FPD）中的MAP技术识别医学图像中的材料的能力提供了显著的益处，包括在标准数字射线照相（DR）设备上测量骨矿物质密度（BMD）的能力。血管造影系统使用不透射线的造影剂（通常是碘溶液）的X射线吸收对比，使体内的血管和器官可视化，并用于辅助诊断和治疗心脏病（冠状动脉造影）或脑部疾病已知碘基造影剂通过造影剂诱导的肾病（CIN）损害肾功能，约2%的患者发生CIN。在高风险患者中增加到20-30%。该项目旨在证明IBEX材料分类方法可以通过材料类型而不是X射线阻断特性来识别造影剂。这提供了在没有对比度损失的情况下对低得多的碘浓度进行成像的可能性，或者使用新型的无害造影剂，其可以通过其与身体结构的材料差异来区分。该项目还将证明IBEX材料分类技术可以真实的实时生成移动造影剂的图像。最后，该项目将试图证明在动态图像中抑制骨骼和组织作为数字减影血管造影（DSA）方法的替代方法。