Dynamic Nuclear Polarization of Aerosols - A Novel Approach for Imaging Water Vapor and Enabling Lung Imaging

气溶胶的动态核极化——一种水蒸气成像和肺部成像的新方法

基本信息

批准号：
10580810
负责人：
Leeor Alon
金额：
$ 20.32万
依托单位：
NEW YORK UNIVERSITY SCHOOL OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-03-01 至 2024-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10580810
关键词：
Address Aerosols Air Airway Disease Anatomy Anesthetics Animal Model Animals Asthma Biological Bronchitis COVID-19 Chronic Obstructive Pulmonary Disease Clinical Compensation Dedications Detection Development Diagnostic Diameter Disease Electronics Equipment Foundations Gases Goals Human Image Imaging Techniques Inhalation Investigation Length Liquid substance Lung Lung diseases Magnetic Resonance Imaging Magnetism Measurement Methods Microscopic Mind Morbidity - disease rate Morphologic artifacts Motion Mus Nebulizer Noise Nuclear Oxygen Particle Size Patients Phase Pneumonia Predisposition Property Protocols documentation Protons Quality of life Radiation Radiation exposure Relaxation Research Research Project Grants Signal Transduction Speed Spirometry System Techniques Technology Assessment Temperature Testing Tissues Toxic effect Ultrasonics Validation Water Work X-Ray Computed Tomography aerosolized biomaterial compatibility clinical implementation cohort cost cost effective density design and construction diagnostic value disease diagnostic flexibility imaging approach imaging modality implementation cost in vivo innovation lung imaging lung volume magnetic field meter microwave electromagnetic radiation novel novel diagnostics novel strategies open source particle portability programs pulmonary function pulmonary symptom respiratory imaging soft tissue technology validation tool transmission process vaping vapor ventilation water vapor

项目摘要

Project Summary Detecting and characterizing lung disorders and their impacts on the airways by imaging is extremely challenging due to the low tissue density. Few options exist to characterize the changes in the microscopic properties of air access and tissue changes in diseases such as asthma, pneumonia, bronchitis, Covid-19, and chronic obstructive pulmonary disease. MRI with hyperpolarized gasses, such as 3He and 129Xe have been used to fill this gap, which however have their own limitations related to cost, complexity of implementation, compatibility of existing equipment, and some non-negligible biological effects of the gasses. This project will deliver an alternative approach, based on aerosolized hyperpolarized water vapor (AHWV), which will be fully biocompatible, portable, compatible with existing imaging hardware, and will allow probing lung volume at different length scales. The approach is based on Overhauser Dynamic Nuclear Polarization (ODNP) of water, followed by aerosolization of hyperpolarized water such that it can be imaged. For this exploratory program, we will develop an open-source, low field (0.2T) ODNP system to hyperpolarize water in the liquid phase that will be rapidly vaporized by an aerosolization reactor. Relaxation properties of water in vapor form will be studied at different magnetic field strengths, temperatures and aerosolization approaches to determine the optimal conditions for vapor polarization, delivery into the measurement volume and optimization of sensitivity. The method will be on a mouse animal model on a 3T animal scanner. Overall, we will establish an effective method to hyperpolarize and aerosolize water and will develop the necessary tools required to acquire hyperpolarized water-in-air images in void-spaces. The study is expected to lay the foundation for this new portable, cost-effective, and flexible imaging modality for the airways.

项目摘要检测和表征肺部疾病及其对气道的影响非常非常由于低组织密度而挑战。很少有选项来表征微观的变化疾病，肺炎，支气管炎，COVID-19和疾病的组织变化的特性慢性阻塞性肺疾病。具有超极化气体的MRI，例如3HE和129xE 用于填补这一空白，但是有其自身的局限性与成本，实施的复杂性，现有设备的兼容性，以及某些气体的不可忽略的生物学作用。这个项目将提供基于雾化超极化水蒸气（AHWV）的替代方法，该方法将完全生物相容性，便携式，与现有成像硬件兼容，并将允许探测肺量不同的长度尺度。该方法基于水的过度大冲动动态核极化（ODNP），然后将超极化水雾化，以便可以成像。对于这个探索性计划，我们将开发一个开源的低场（0.2T）ODNP系统，以在液相中超极化水通过雾化反应器快速蒸发。将研究蒸气形式的水的放松特性在不同的磁场强度，温度和雾化方法以确定最佳蒸气极化的条件，输送到测量量以及灵敏度的优化。这方法将在3T动物扫描仪上的小鼠动物模型上。总体而言，我们将建立一个有效的超极化和雾化水的方法，并将开发获取所需的必要工具在空间空间中的超极化水图像。该研究有望为这一新的基础奠定基础呼吸道的便携式，具有成本效益和灵活的成像方式。